Y
Yuta Kochi
Researcher at Tokyo Medical and Dental University
Publications - 106
Citations - 7343
Yuta Kochi is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 37, co-authored 90 publications receiving 5972 citations. Previous affiliations of Yuta Kochi include Japanese Ministry of Health, Labour and Welfare & University of Tokyo.
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Journal ArticleDOI
Genetics of rheumatoid arthritis contributes to biology and drug discovery
Yukinori Okada,Yukinori Okada,Di Wu,Di Wu,Di Wu,Gosia Trynka,Gosia Trynka,Towfique Raj,Towfique Raj,Chikashi Terao,Katsunori Ikari,Yuta Kochi,Koichiro Ohmura,Akari Suzuki,Shinji Yoshida,Robert R. Graham,A. Manoharan,Ward Ortmann,Tushar Bhangale,Joshua C. Denny,Robert J. Carroll,Anne E. Eyler,Jeff Greenberg,Joel M. Kremer,Dimitrios A. Pappas,Lei Jiang,Jian Yin,Lingying Ye,Ding Feng Su,Jian Yang,Gang Xie,E.C. Keystone,Harm-Jan Westra,Tõnu Esko,Tõnu Esko,Tõnu Esko,Andres Metspalu,Xuezhong Zhou,Namrata Gupta,Daniel B. Mirel,Eli A. Stahl,Dorothee Diogo,Dorothee Diogo,Jing Cui,Jing Cui,Katherine P. Liao,Katherine P. Liao,Michael H. Guo,Michael H. Guo,Keiko Myouzen,Takahisa Kawaguchi,Marieke J H Coenen,Piet L. C. M. van Riel,Mart A F J van de Laar,Henk-Jan Guchelaar,Tom W J Huizinga,Philippe Dieudé,Xavier Mariette,S. Louis Bridges,Alexandra Zhernakova,Alexandra Zhernakova,René E. M. Toes,Paul P. Tak,Paul P. Tak,Paul P. Tak,Corinne Miceli-Richard,So Young Bang,Hye Soon Lee,Javier Martin,Miguel A. Gonzalez-Gay,Luis Rodriguez-Rodriguez,Solbritt Rantapää-Dahlqvist,Lisbeth Ärlestig,Hyon K. Choi,Hyon K. Choi,Yoichiro Kamatani,Pilar Galan,Mark Lathrop,Steve Eyre,Steve Eyre,John Bowes,John Bowes,Anne Barton,Niek de Vries,Larry W. Moreland,Lindsey A. Criswell,Elizabeth W. Karlson,Atsuo Taniguchi,Ryo Yamada,Michiaki Kubo,Jun Liu,Sang Cheol Bae,Jane Worthington,Jane Worthington,Leonid Padyukov,Lars Klareskog,Peter K. Gregersen,Soumya Raychaudhuri,Soumya Raychaudhuri,Barbara E. Stranger,Philip L. De Jager,Philip L. De Jager,Lude Franke,Peter M. Visscher,Matthew A. Brown,Hisashi Yamanaka,Tsuneyo Mimori,Atsushi Takahashi,Huji Xu,Timothy W. Behrens,Katherine A. Siminovitch,Shigeki Momohara,Fumihiko Matsuda,Kazuhiko Yamamoto,Robert M. Plenge,Robert M. Plenge +115 more
TL;DR: A genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries provides empirical evidence that the genetics of RA can provide important information for drug discovery, and sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis.
Journal ArticleDOI
An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis.
Shinya Tokuhiro,Ryo Yamada,Xiaotian Chang,Akari Suzuki,Yuta Kochi,Tetsuji Sawada,Masakatsu Suzuki,Miyuki Nagasaki,Masahiko Ohtsuki,Mitsuru Ono,Hidehiko Furukawa,Masakazu Nagashima,Shinichi Yoshino,Akihiko Mabuchi,Akihiro Sekine,Susumu Saito,Atsushi Takahashi,Tatsuhiko Tsunoda,Yusuke Nakamura,Kazuhiko Yamamoto +19 more
TL;DR: The data indicate that the regulation of SLC22A4 expression by RUNX1 is associated with susceptibility to rheumatoid arthritis, which may represent an example of an epistatic effect of two genes on this disorder.
Journal ArticleDOI
A functional variant in FCRL3 , encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities
Yuta Kochi,Ryo Yamada,Akari Suzuki,John B. Harley,John B. Harley,John B. Harley,Senji Shirasawa,Tetsuji Sawada,Sang Cheol Bae,Shinya Tokuhiro,Xiaotian Chang,Akihiro Sekine,Atsushi Takahashi,Tatsuhiko Tsunoda,Yozo Ohnishi,Kenneth M. Kaufman,Kenneth M. Kaufman,Kenneth M. Kaufman,Changsoo Paul Kang,Changwon Kang,Shigeru Otsubo,Wako Yumura,Akio Mimori,Takao Koike,Yusuke Nakamura,Takehiko Sasazuki,Kazuhiko Yamamoto +26 more
TL;DR: A SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis is identified and this polymorphism alters the binding affinity of nuclear factor-κB and regulatesFCRL3 expression.
Journal ArticleDOI
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
Yukinori Okada,Chikashi Terao,Katsunori Ikari,Yuta Kochi,Koichiro Ohmura,Akari Suzuki,Takahisa Kawaguchi,Eli A. Stahl,Eli A. Stahl,Fina A S Kurreeman,Fina A S Kurreeman,Fina A S Kurreeman,Nao Nishida,Hiroko Ohmiya,Keiko Myouzen,Meiko Takahashi,Tetsuji Sawada,Yuichi Nishioka,Masao Yukioka,Tsukasa Matsubara,Shigeyuki Wakitani,Ryota Teshima,Shigeto Tohma,Kiyoshi Takasugi,Kota Shimada,Akira Murasawa,Shigeru Honjo,Keitaro Matsuo,Hideo Tanaka,Kazuo Tajima,Taku Suzuki,Takuji Iwamoto,Yoshiya Kawamura,Hisashi Tanii,Yuji Okazaki,Tsukasa Sasaki,Peter K. Gregersen,Leonid Padyukov,Jane Worthington,Katherine A. Siminovitch,Mark Lathrop,Atsuo Taniguchi,Atsushi Takahashi,Katsushi Tokunaga,Michiaki Kubo,Yusuke Nakamura,Naoyuki Kamatani,Tsuneyo Mimori,Robert M. Plenge,Robert M. Plenge,Hisashi Yamanaka,Shigeki Momohara,Ryo Yamada,Fumihiko Matsuda,Kazuhiko Yamamoto +54 more
TL;DR: This study identified nine loci newly associated with rheumatoid arthritis at a threshold of P < 5.0 × 10−8, including B3GNT2, ANXA3, CSF2, CD83, NFKBIE, ARID5B, PDE2A-ARAP1, PLD4 and PTPN2.
Journal ArticleDOI
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.
Yuta Kochi,Yukinori Okada,Akari Suzuki,Katsunori Ikari,Chikashi Terao,Atsushi Takahashi,Keiko Yamazaki,Naoya Hosono,Keiko Myouzen,Tatsuhiko Tsunoda,Naoyuki Kamatani,Tatsuya Furuichi,Shiro Ikegawa,Koichiro Ohmura,Tsuneyo Mimori,Fumihiko Matsuda,Takuji Iwamoto,Shigeki Momohara,Hisashi Yamanaka,Ryo Yamada,Michiaki Kubo,Yusuke Nakamura,Kazuhiko Yamamoto +22 more
TL;DR: The results suggest that CCR6 is critically involved in IL-17–driven autoimmunity in human diseases, and is associated with susceptibility to Graves' and Crohn's diseases.