T
Tetsuji Sawada
Researcher at Tokyo Medical University
Publications - 76
Citations - 4769
Tetsuji Sawada is an academic researcher from Tokyo Medical University. The author has contributed to research in topics: Rheumatoid arthritis & Arthritis. The author has an hindex of 29, co-authored 66 publications receiving 4401 citations. Previous affiliations of Tetsuji Sawada include Kyoto University & Saitama Medical University.
Papers
More filters
Journal ArticleDOI
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis.
Akari Suzuki,Ryo Yamada,Xiaotian Chang,Shinya Tokuhiro,Tetsuji Sawada,Masakatsu Suzuki,Miyuki Nagasaki,Makiko Nakayama-Hamada,Reimi Kawaida,Mitsuru Ono,Masahiko Ohtsuki,Hidehiko Furukawa,Shinichi Yoshino,Masao Yukioka,Shigeto Tohma,Tsukasa Matsubara,Shigeyuki Wakitani,Ryota Teshima,Yuichi Nishioka,Akihiro Sekine,Aritoshi Iida,Atsushi Takahashi,Tatsuhiko Tsunoda,Yusuke Nakamura,Kazuhiko Yamamoto +24 more
TL;DR: The results imply that the PADI4 haplotype associated with susceptibility to rheumatoid arthritis increases production of citrullinated peptides acting as autoantigens, resulting in heightened risk of developing the disease.
Journal ArticleDOI
An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis.
Shinya Tokuhiro,Ryo Yamada,Xiaotian Chang,Akari Suzuki,Yuta Kochi,Tetsuji Sawada,Masakatsu Suzuki,Miyuki Nagasaki,Masahiko Ohtsuki,Mitsuru Ono,Hidehiko Furukawa,Masakazu Nagashima,Shinichi Yoshino,Akihiko Mabuchi,Akihiro Sekine,Susumu Saito,Atsushi Takahashi,Tatsuhiko Tsunoda,Yusuke Nakamura,Kazuhiko Yamamoto +19 more
TL;DR: The data indicate that the regulation of SLC22A4 expression by RUNX1 is associated with susceptibility to rheumatoid arthritis, which may represent an example of an epistatic effect of two genes on this disorder.
Journal ArticleDOI
A functional variant in FCRL3 , encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities
Yuta Kochi,Ryo Yamada,Akari Suzuki,John B. Harley,John B. Harley,John B. Harley,Senji Shirasawa,Tetsuji Sawada,Sang Cheol Bae,Shinya Tokuhiro,Xiaotian Chang,Akihiro Sekine,Atsushi Takahashi,Tatsuhiko Tsunoda,Yozo Ohnishi,Kenneth M. Kaufman,Kenneth M. Kaufman,Kenneth M. Kaufman,Changsoo Paul Kang,Changwon Kang,Shigeru Otsubo,Wako Yumura,Akio Mimori,Takao Koike,Yusuke Nakamura,Takehiko Sasazuki,Kazuhiko Yamamoto +26 more
TL;DR: A SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis is identified and this polymorphism alters the binding affinity of nuclear factor-κB and regulatesFCRL3 expression.
Journal ArticleDOI
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
Yukinori Okada,Chikashi Terao,Katsunori Ikari,Yuta Kochi,Koichiro Ohmura,Akari Suzuki,Takahisa Kawaguchi,Eli A. Stahl,Eli A. Stahl,Fina A S Kurreeman,Fina A S Kurreeman,Fina A S Kurreeman,Nao Nishida,Hiroko Ohmiya,Keiko Myouzen,Meiko Takahashi,Tetsuji Sawada,Yuichi Nishioka,Masao Yukioka,Tsukasa Matsubara,Shigeyuki Wakitani,Ryota Teshima,Shigeto Tohma,Kiyoshi Takasugi,Kota Shimada,Akira Murasawa,Shigeru Honjo,Keitaro Matsuo,Hideo Tanaka,Kazuo Tajima,Taku Suzuki,Takuji Iwamoto,Yoshiya Kawamura,Hisashi Tanii,Yuji Okazaki,Tsukasa Sasaki,Peter K. Gregersen,Leonid Padyukov,Jane Worthington,Katherine A. Siminovitch,Mark Lathrop,Atsuo Taniguchi,Atsushi Takahashi,Katsushi Tokunaga,Michiaki Kubo,Yusuke Nakamura,Naoyuki Kamatani,Tsuneyo Mimori,Robert M. Plenge,Robert M. Plenge,Hisashi Yamanaka,Shigeki Momohara,Ryo Yamada,Fumihiko Matsuda,Kazuhiko Yamamoto +54 more
TL;DR: This study identified nine loci newly associated with rheumatoid arthritis at a threshold of P < 5.0 × 10−8, including B3GNT2, ANXA3, CSF2, CD83, NFKBIE, ARID5B, PDE2A-ARAP1, PLD4 and PTPN2.
Journal ArticleDOI
Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritis
Xiaotian Chang,Ryo Yamada,Akari Suzuki,Tetsuji Sawada,Shinichi Yoshino,Shinya Tokuhiro,Kazuhiko Yamamoto +6 more
TL;DR: The results showed that PADI4 is mainly distributed in cells of various haematopoietic lineages and expressed at high levels in the inflamed RA synovium and the notion that citrullinated fibrin is a potential antigen of RA autoimmunity is supported.