A
Alan Ashworth
Researcher at University of California, San Francisco
Publications - 589
Citations - 82138
Alan Ashworth is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 134, co-authored 578 publications receiving 72089 citations. Previous affiliations of Alan Ashworth include Imperial College London & Papworth Hospital.
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Nichola Johnson,Kate Walker,Lorna Gibson,Nick Orr,Elizabeth Folkerd,Ben P. Haynes,Claire Palles,Ben Coupland,Minouk J. Schoemaker,Michael P. Jones,Peter Broderick,Elinor J. Sawyer,Michael J. Kerin,Ian P. M. Tomlinson,Marketa Zvelebil,Sarah Chilcott-Burns,Katarzyna Tomczyk,Gemma Simpson,Jill Williamson,Stephen G. Hillier,Gillian Ross,Richard S. Houlston,Anthony J. Swerdlow,Alan Ashworth,Mitch Dowsett,Julian Peto,Olivia Fletcher,St Thomas +27 more
TL;DR: The aim was to identify common variants in genes involved in sex steroid synthesis or metabolism that are associated with hormone levels and the risk of breast cancer in women.
Journal ArticleDOI
Frontal lobe or `nonspecific' dementias are genetically heterogeneous
Alan Ashworth,Jeremy P Brown,Susanne Gydesen,Sven Asger Sørensen,Martin N. Rossor,John Hardy,John Collinge +6 more
TL;DR: The degenerative dementias are among the most common of serious diseases and there are no effective treatments, but many cases lack the distinctive pathologic features that allow such histologic subclassification.
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Abstract PD15-08: Window of opportunity trial of neoadjuvant olaparib and durvalumab for triple negative or low ER-positive breast cancer
Seock-Ah Im,Kyung Eun Lee,Ahrum Min,Dae Won Lee,Tae Yong Kim,Han Suk Ryu,Jiwon Koh,Gi Jeong Cheon,Yoon-Jung Shin,Yu C Kim,Hyeong-Gon Moon,Wonshik Han,Han-Byoel Lee,Morgan E. Diolaiti,David A. Quigley,Alan Ashworth,Nariya Cho +16 more
TL;DR: Olaparib and durvalumab followed by standard neoadjuvant chemotherapy shows very high pCR rate in TNBC or low ER+ stage II/III breast cancer.
Journal ArticleDOI
Chronic mould exposure as a risk factor for severe community acquired pneumonia in a patient requiring extra corporeal membrane oxygenation.
Stephanie Thomas,Ibrahim A. Hassan,Julian Barker,Alan Ashworth,Anita Barnes,Igor Fedor,Lee Feddy,Tim Hayes,Ignacio Malagon,Sarah Stirling,Lajos Szentgyorgyi,K J Mutton,Malcolm Richardson +12 more
TL;DR: It is hypothesized that poor domiciliary conditions may make an underestimated contribution to community respiratory disease and may present as acute and severe illness with non-typical pathogens identified.
Proceedings ArticleDOI
Abstract 4045: Intragenic ATM methylation in peripheral blood DNA as a biomarker of breast cancer risk
Kevin Brennan,Montserrat Garcias-Closas,Nick Orr,Olivia Fletcher,Michael Jones,Alan Ashworth,Anthony J. Swerdlow,Elio Riboli,Paolo Vineis,Mirren Dorronsosro,Françoise Clavel,Salvatore Panico,N. Charlotte Onland-Moret,Dimitrios Trichopoulos,Rudolf Kaaks,Kay-Tee Khaw,Robert M Brown,James M. Flanagan +17 more
TL;DR: It is indicated that WBC DNA methylation levels at ATM could be a marker of breast cancer risk and further support the pursuit of epigenome-wide association studies in peripheral bloodDNA methylation.