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Alan Ashworth
Researcher at University of California, San Francisco
Publications - 589
Citations - 82138
Alan Ashworth is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 134, co-authored 578 publications receiving 72089 citations. Previous affiliations of Alan Ashworth include Imperial College London & Papworth Hospital.
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Determinants of age at menarche in the UK: analyses from the Breakthrough Generations Study.
TL;DR: Age at menarche was influenced by both pre- and post-natal factors, and these factors may affect breast cancer risk through this route.
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Challenges translating breast cancer gene signatures into the clinic
TL;DR: The hurdles in the development and validation of molecular classification systems, and prognostic and predictive signatures based on microarray gene-expression profiling are discussed and it is suggested that similar challenges are likely to be encountered in translating next-generation sequencing data into clinically useful information.
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Treatment with olaparib in a patient with PTEN-deficient endometrioid endometrial cancer
Martin Forster,Konstantin J. Dedes,Shahneen Sandhu,Sophia Frentzas,Rebecca Kristeleit,Alan Ashworth,Christopher J. Poole,Britta Weigelt,Stan B. Kaye,L Rhoda Molife +9 more
TL;DR: The patient remained alive for 10 months after completing olaparib, having gone on to derive further clinical benefit from repeat exposure to platinum-based therapy, and was suggested to be another predictive marker for sensitivity to PARP inhibitors.
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DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells
TL;DR: It is shown that like BRCA2, DSS1 is required for DNA damage‐induced RAD51 focus formation and for the maintenance of genomic stability, indicating a function conserved from lower eukaryotes to humans.
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New complexities for BRCA1 and BRCA2
Peter Kerr,Alan Ashworth +1 more
TL;DR: A large number of diverse functions have been attributed to the BRCa1 and BRCA2 breast cancer susceptibility genes, and recent progress is reviewed.