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Alan Ashworth
Researcher at University of California, San Francisco
Publications - 589
Citations - 82138
Alan Ashworth is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 134, co-authored 578 publications receiving 72089 citations. Previous affiliations of Alan Ashworth include Imperial College London & Papworth Hospital.
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Journal Article
The amino acid sequence of a mammalian MAP kinase kinase.
TL;DR: The amino acid sequence of the dual specificity mitogen-activated protein kinase kinase (MAPKK) has been determined by cDNA cloning and amino acid sequencing.
Journal ArticleDOI
PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study
Maryou B K Lambros,Rachael Natrajan,Felipe C. Geyer,María Ángeles López-García,María Ángeles López-García,Konstantin J. Dedes,Kay Savage,Magali Lacroix-Triki,Robin L. Jones,Christopher J. Lord,Spiros Linardopoulos,Alan Ashworth,Jorge S. Reis-Filho +12 more
TL;DR: PPM1D is consistently overexpressed when amplified; however, P PM1D overexpression is more pervasive than gene amplification, suggesting the presence of a ‘firestorm’ genetic profile.
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Poly (ADP-ribose) polymerase (PARP) inhibitors for the treatment of advanced germline BRCA2 mutant prostate cancer
Shahneen Sandhu,Shahneen Sandhu,Aurelius Omlin,Aurelius Omlin,Lucy Hylands,Susana Miranda,Louise J. Barber,Ruth Riisnaes,Alison Reid,Alison Reid,Gerhardt Attard,Gerhardt Attard,Lina Chen,Iwanka Kozarewa,Heidrun Gevensleben,James Campbell,Kerry Fenwick,Ioannis Assiotis,David Olmos,David Olmos,T. A. Yap,T. A. Yap,Peter C.C. Fong,Peter C.C. Fong,Nina Tunariu,Dow-Mu Koh,L. R. Molife,L. R. Molife,Stan B. Kaye,Stan B. Kaye,Christopher J. Lord,Alan Ashworth,J.S. de Bono,J.S. de Bono +33 more
TL;DR: A large number of patients in the RADIANT-3 trial had at least one prior chemotherapy session, and the impact of prior chemotherapy on progression-free survival in patients with advanced pancreatic neuroendocrine tumors (pNET) was unclear.
Journal ArticleDOI
LKB1 Kinase: Master and Commander of Metabolism and Polarity
James Spicer,Alan Ashworth +1 more
TL;DR: LKB1, the product of a tumour suppressor gene, is a serine/threonine kinase that coordinates disparate cellular processes, providing new insight into the regulation of cell polarity and energy-generating metabolism.
Journal ArticleDOI
BRCA1 and BRCA2.
David Bertwistle,Alan Ashworth +1 more
TL;DR: Hongbing Z, Tombline G, Weber BL, and Weber BL: BRCA1, BRCa2, and DNA damage response: collision or collusion?