A
Alan Ashworth
Researcher at University of California, San Francisco
Publications - 589
Citations - 82138
Alan Ashworth is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 134, co-authored 578 publications receiving 72089 citations. Previous affiliations of Alan Ashworth include Imperial College London & Papworth Hospital.
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Journal ArticleDOI
Developing rational drug combination strategies for PARP inhibitors.
Farah L. Rehman,Richard Elliott,Rachel Brough,Jessica Frankum,Anan Ragab,Christopher J. Lord,Alan Ashworth +6 more
TL;DR: The recent clinical development of Poly (ADP-ribose) polymerase (PARP) inhibitors has provided formal proof-of-concept that synthetic lethal approaches can be used to treat cancer.
Posted ContentDOI
An Inducible Cre Mouse with Preferential Activity in Vascular Smooth Muscle Evades a Previously Lethal Intestinal Phenotype
Ganesh Warthi,Jessica L. Faulkner,Jaser Doja,A. R. Ghanam,Pan Gao,Allison C. Yang,Orazio J. Slivano,Candee Barris,Taylor C. Kress,Scott D. Zawieja,Susan H. Griffin,Xiaoling Xie,Alan Ashworth,Christine K. Christie,William B. Bryant,Ajay Kumar,Michael Davis,Xiaochun Long,Lin Gan,Eric J. Belin de Chantemèle,Qing Lyu,Joseph M. Miano +21 more
TL;DR: The Itga8- CreERT2 mouse is established as an alternative to existing SMC Cre strains, including Myh11-CreERT2, where SMC gene loss results in visceral myopathies that obfuscate accurate phenotyping in vascular SMCs.
The Breast Cancer Susceptibility Genes BRCA1 and BRCA2
Anastasia Gabriel,Alan Ashworth +1 more
TL;DR: Two breast cancer susceptibility genes have been mapped and cloned, and mutations in these genes account for most families with four or more cases of breast cancer diagnosed before age 60.
Journal ArticleDOI
Two cases of community acquired Legionella pneumophila non‐serogroup 1 in patients undergoing extra corporeal membrane oxygenation for severe respiratory failure
Stephanie Thomas,Ibrahim A. Hassan,Julian Barker,Alan Ashworth,Anita Barnes,Lee Feddy,Igor Fedor,Tim Hayes,Ignacio Malagon,Sarah Stirling,Lajos Szentgyorgyi,K J Mutton,Timothy G. Harrison +12 more
TL;DR: Recognition of the potential for non‐serogroup 1 strains to cause severe LD should prompt requests for further investigations including Legionella PCR in patients who present with suggestive symptoms when the urine antigen is negative.
Proceedings ArticleDOI
Abstract 1225: Rare variants in DNA damage repair genes are associated with male breast cancer predisposition
Sarah Maguire,Katarzyna Tomczyk,Eleni Perrakis,Edward J. Saunders,Daniel Leongamornlert,Zsofia Kote-Jarai,Rosalind A. Eeles,Montserrat Garcia-Closas,Paul D.P. Pharoah,Douglas F. Easton,Christopher J. Lord,Alan Ashworth,Anthony J. Swerdlow,Nick Orr +13 more