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Alan Ashworth
Researcher at University of California, San Francisco
Publications - 589
Citations - 82138
Alan Ashworth is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 134, co-authored 578 publications receiving 72089 citations. Previous affiliations of Alan Ashworth include Imperial College London & Papworth Hospital.
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Functional analysis of drosophila melanogaster BRCA2 in DNA repair
TL;DR: It is demonstrated that depletion of dmbrca2 from Drosophila cells induces sensitivity to DNA damage induced by irradiation or treatment with hydroxyurea and depletion in cells is synthetically lethal with deficiency in other DNA repair proteins including dmparp.
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Structure and expression of the gene encoding mouse t-complex polypeptide (Tcp-1).
Hiroshi Kubota,Keith R. Willison,Alan Ashworth,Masami Nozaki,Hiroshi Miyamoto,Hiroyuki Yamamoto,Aizo Matsushiro,Takayoshi Morita +7 more
TL;DR: The results suggest that the expression of the Tcp-1 gene may be regulated spatially and temporally in embryonic and adult mice by transcriptional control or by mRNA stability.
Journal ArticleDOI
Using Functional Genetics to Understand Breast Cancer Biology
Alan Ashworth,René Bernards +1 more
TL;DR: How functional genetic studies can help us understand the biology of breast cancer, how it can be used to identify novel targets for breast cancer therapy, and howIt can help in the identification of those patients that are most likely to respond to a given therapy are described.
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An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer.
Isaac Garcia-Murillas,Rachel Sharpe,Alex Pearson,James Campbell,Rachael Natrajan,Alan Ashworth,Nicholas C. Turner +6 more
TL;DR: The data indicate that amplification of the GNAS locus may contribute to the pathogenesis of breast cancer, and highlight a previously unrecognised role for the GNas XLαs variant in cancer.
Journal ArticleDOI
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
Maria Escala-Garcia,Jean Abraham,Irene L. Andrulis,Hoda Anton-Culver,Volker Arndt,Alan Ashworth,Paul L. Auer,Paul L. Auer,Päivi Auvinen,Matthias W. Beckmann,Jonathan Beesley,Sabine Behrens,Javier Benitez,Marina Bermisheva,Carl Blomqvist,Carl Blomqvist,William J. Blot,Natalia Bogdanova,Stig E. Bojesen,Stig E. Bojesen,Manjeet K. Bolla,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Hermann Brenner,Sara Y. Brucker,Barbara Burwinkel,Barbara Burwinkel,Carlos Caldas,Carlos Caldas,Federico Canzian,Jenny Chang-Claude,Jenny Chang-Claude,Stephen J. Chanock,Suet-Feung Chin,Christine L. Clarke,Fergus J. Couch,Angela Cox,Simon S. Cross,Kamila Czene,Mary B. Daly,Joe Dennis,Peter Devilee,Janet A. Dunn,Alison M. Dunning,Miriam Dwek,Helena M. Earl,Diana Eccles,A. Heather Eliassen,Carolina Ellberg,D. Gareth Evans,Peter A. Fasching,Peter A. Fasching,Jonine D. Figueroa,Jonine D. Figueroa,Jonine D. Figueroa,Henrik Flyger,Manuela Gago-Dominguez,Manuela Gago-Dominguez,Susan M. Gapstur,Montserrat Garcia-Closas,José A. García-Sáenz,Mia M. Gaudet,Angela George,Graham G. Giles,Graham G. Giles,Graham G. Giles,David E. Goldgar,Anna González-Neira,Mervi Grip,Pascal Guénel,Qi Guo,Christopher A. Haiman,Niclas Håkansson,Ute Hamann,Patricia Harrington,Louise Hiller,Maartje J. Hooning,John L. Hopper,Anthony Howell,Chiun-Sheng Huang,Guanmengqian Huang,David J. Hunter,David J. Hunter,Anna Jakubowska,Anna Jakubowska,Esther M. John,Rudolf Kaaks,Pooja Middha Kapoor,Pooja Middha Kapoor,Renske Keeman,Cari M. Kitahara,Linetta B. Koppert,Peter Kraft,Vessela N. Kristensen,Vessela N. Kristensen,Diether Lambrechts,Loic Le Marchand,Flavio Lejbkowicz,Annika Lindblom,Jan Lubinski,Arto Mannermaa,Mehdi Manoochehri,Siranoush Manoukian,Sara Margolin,Maria Elena Martinez,Tabea Maurer,Dimitrios Mavroudis,Alfons Meindl,Roger L. Milne,Roger L. Milne,Roger L. Milne,Anna Marie Mulligan,Anna Marie Mulligan,Susan L. Neuhausen,Heli Nevanlinna,William G. Newman,Andrew F. Olshan,Janet E. Olson,Håkan Olsson,Nick Orr,Paolo Peterlongo,Christos Petridis,Ross L. Prentice,Nadege Presneau,Kevin Punie,Dhanya Ramachandran,Gad Rennert,Atocha Romero,Mythily Sachchithananthan,Emmanouil Saloustros,Elinor J. Sawyer,Rita K. Schmutzler,Lukas Schwentner,Christopher G. Scott,Jacques Simard,Christof Sohn,Melissa C. Southey,Melissa C. Southey,Anthony J. Swerdlow,Rulla M. Tamimi,William J. Tapper,Manuel R. Teixeira,Mary Beth Terry,Heather Thorne,Heather Thorne,Rob A. E. M. Tollenaar,Ian Tomlinson,Ian Tomlinson,Melissa A. Troester,Thérèse Truong,Clare Turnbull,Celine M. Vachon,Lizet E. van der Kolk,Qin Wang,Robert Winqvist,Alicja Wolk,Alicja Wolk,Xiaohong R. Yang,Argyrios Ziogas,Paul D.P. Pharoah,Per Hall,Lodewyk F. A. Wessels,Lodewyk F. A. Wessels,Georgia Chenevix-Trench,Gary D. Bader,Thilo Dörk,Douglas F. Easton,Sander Canisius,Marjanka K. Schmidt +171 more
TL;DR: A network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis is adapted and four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease are identified.