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Alan Ashworth
Researcher at University of California, San Francisco
Publications - 589
Citations - 82138
Alan Ashworth is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 134, co-authored 578 publications receiving 72089 citations. Previous affiliations of Alan Ashworth include Imperial College London & Papworth Hospital.
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Journal ArticleDOI
Molecular genetic characterisation of frontotemporal dementia on chromosome 3.
Alan Ashworth,Sarah E. Lloyd,J Brown,Susanne Gydesen,Sven Asger Sørensen,A Brun,Elisabet Englund,C. Humphreys,David E. Housman,M. Badura,Vincent P. Stanton,K. Taylor,J. Cameron,D. Munroe,J. Johansson,Martin N. Rossor,Elizabeth M. C. Fisher,John Collinge +17 more
TL;DR: A locus causing familial nonspecific dementia to the centromeric region of chromosome 3 in a pedigree from the Jutland area of Denmark shows anticipation which is suggestive of trinucleotide repeat expansion involvement, and strategies to clone the mutant gene via its putative associated trinuclear repeat sequence are outlined.
Journal ArticleDOI
Temporal Stability and Determinants of White Blood Cell DNA Methylation in the Breakthrough Generations Study
James M. Flanagan,Mark N. Brook,Nick Orr,Katarzyna Tomczyk,Penny Coulson,Olivia Fletcher,Michael Jones,Minouk J. Schoemaker,Alan Ashworth,Anthony J. Swerdlow,Robert S. Brown,Robert S. Brown,Montserrat Garcia-Closas +12 more
TL;DR: Both cross-sectional and longitudinal data analyses provided strong evidence for associations between changes in methylation levels and aging and support for the use of white blood cell DNA methylation as a biomarker of exposure in EWAS.
Journal ArticleDOI
The proteasome is involved in determining differential utilization of double-strand break repair pathways.
TL;DR: It is demonstrated that inhibition of proteasome proteolytic activity results in an increase in the utilization of potentially mutagenic single-strand annealing at the expense of a reduction in the level of error-free gene conversion, confirming a functional link between DSB repair and proteasomal activity.
Journal ArticleDOI
Frequent somatic deletion of the 13q12.3 locus encompassing BRCA2 in chronic lymphocytic leukemia
TL;DR: Interphase cytogenetics data provide evidence for the existence of a new tumor suppressor locus in B-cell CLL located at 13q12.3.
Posted ContentDOI
Detection of early stage pancreatic cancer using 5-hydroxymethylcytosine signatures in circulating cell free DNA
Francois Collin,Yuhong Ning,Tierney Phillips,Erin McCarthy,Aaron Scott,Christopher K. Ellison,Chin-Jen Ku,Gulfem Guler,Kim Chau,Alan Ashworth,Stephen R. Quake,Samuel Levy +11 more
TL;DR: It is found that 5hmC sites are enriched in a disease and stage specific manner in exons, 3’UTRs and transcription termination sites with progressive disease suggesting increased transcriptional activity.