A
Alan Ashworth
Researcher at University of California, San Francisco
Publications - 589
Citations - 82138
Alan Ashworth is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 134, co-authored 578 publications receiving 72089 citations. Previous affiliations of Alan Ashworth include Imperial College London & Papworth Hospital.
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The mouse Ftzf1 gene required for gonadal and adrenal development maps to mouse chromosome 2.
Sally Swift,Alan Ashworth +1 more
TL;DR: The nuclear steroid receptor-like protein steroidogenic factor 1 (SF1), encoded by the fuschi tarazu factor-1 (Ftzf1) gene, is essential for the development of steroidogenic organs and normal sexual differentiation.
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X-Chromosome inactivation: X marks the spot for BRCA1
TL;DR: X-chromosome inactivation equalizes the dosage of X-linked genes in XX females with that in XY males, and reveals that the BRCA1 breast cancer susceptibility gene has an important function in this epigenetic phenomenon.
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Autoantibody landscape in patients with advanced prostate cancer
William S. Chen,Winston A. Haynes,Rebecca Waitz,Kathy Kamath,Agustin Vega-Crespo,Raunak Shrestha,Minlu Zhang,Adam Foye,Ignacio Baselga Carretero,Ivan Perez Garcilazo,Meng Zhang,Shuang G Zhao,Martin Sjöström,David A. Quigley,Jonathan Chou,Tomasz M. Beer,Matthew Rettig,Martin E. Gleave,Christopher P. Evans,Primo N. Lara,Kim N. Chi,R.E. Reiter,Joshi J. Alumkal,Joshi J. Alumkal,Alan Ashworth,Rahul Aggarwal,Rahul Aggarwal,Eric J. Small,Patrick S. Daugherty,Antoni Ribas,David Y. Oh,John Shon,Felix Y. Feng +32 more
TL;DR: The first large-scale profiling of autoantibodies in advanced prostate cancer is presented, utilizing a new antibody profiling approach to reveal novel cancer-specific antigens and epitopes.
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Reproducibility of Estradiol and Testosterone Levels in Postmenopausal Women Over 5 Years: Results From the Breakthrough Generations Study
Michael Jones,Minouk J. Schoemaker,Megan Rae,Elizabeth Folkerd,Mitch Dowsett,Alan Ashworth,Anthony J. Swerdlow +6 more
TL;DR: The results suggest that other factors account for within-woman variation in these sex hormones, including change in age, alcohol consumption, smoking, exercise, time between waking and blood collection, or season.
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Patchy fur, a mouse coat mutation associated with X-Y nondisjunction, maps to the pseudoautosomal boundary region.
Olga Korobova,Priscilla W. Lane,Jo K. Perry,Steve Palmer,Alan Ashworth,Muriel T. Davisson,Norman Arnheim +6 more
TL;DR: Patchy fur is a semidominant X-linked mutation in the mouse, resulting in a sparse coat and the meiotic nondisjunction phenotype may result from a chromosomal rearrangement that includes pseudoautosomal sequences and affects XY pairing.