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Alan Ashworth
Researcher at University of California, San Francisco
Publications - 589
Citations - 82138
Alan Ashworth is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 134, co-authored 578 publications receiving 72089 citations. Previous affiliations of Alan Ashworth include Imperial College London & Papworth Hospital.
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Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation
TL;DR: The data support a direct role for Xist in the initiation of X inactivation, and the earliest Xist expression in morulae and blastocysts is imprinted, resulting in specific expression of the paternal Xist allele.
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Breast cancer molecular profiling with single sample predictors: a retrospective analysis
Britta Weigelt,Alan Mackay,Roger A'Hern,Rachael Natrajan,David S.P. Tan,Mitch Dowsett,Mitch Dowsett,Alan Ashworth,Jorge S. Reis-Filho +8 more
TL;DR: Although every SSP identifies molecular subtypes with similar survival, they do not reliably assign the same patients to the same molecular subtype, so stringent standardisation of methodologies and definitions for identification of breast cancer molecular sub types is needed.
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CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells
TL;DR: Differential staining of mammary epithelial cells for CD24 can be used to simultaneously isolate pure populations of non-epithelial, myoepithel/basal and luminal epithelialcells, which is key for understanding mammaries epithelial stem cells in normal tissue biology and carcinogenesis.
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MAP kinase phosphatases
Aspasia Theodosiou,Alan Ashworth +1 more
TL;DR: An emerging family of structurally distinct dual-specificity serine, threonine and tyrosine phosphatases that act on MAP kinases consists of ten members in mammals, and members have been found in animals, plants and yeast.
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Translating cancer research into targeted therapeutics
TL;DR: The issues involved in cancer drug development are highlighted and ways in which this process can be improved and expedited are suggested.