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Alan Ashworth
Researcher at University of California, San Francisco
Publications - 589
Citations - 82138
Alan Ashworth is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 134, co-authored 578 publications receiving 72089 citations. Previous affiliations of Alan Ashworth include Imperial College London & Papworth Hospital.
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The Breakthrough Generations Study: design of a long-term UK cohort study to investigate breast cancer aetiology.
Anthony J. Swerdlow,Michael Jones,Minouk J. Schoemaker,J Hemming,David Thomas,J Williamson,J Williamson,Alan Ashworth +7 more
TL;DR: The ‘generational’ recruitment method has enabled recruitment of a large cohort who appear to have the commitment to enable long-term continuing data and sample collection, to investigate the effects of changing endogenous and exogenous factors on cancer risk.
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The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase.
TL;DR: It is shown that Lkb1 is most likely a nuclear protein and a nuclear localization signal within the protein sequence is defined, indicating that the defect in Peutz-Jeghers syndrome may directly result in changes in gene expression in the nucleus of target cells.
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A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D
Sydonia Rayter,Richard Elliott,J. Travers,Martin G. Rowlands,T. B. Richardson,K. Boxall,Keith Jones,Spiros Linardopoulos,Paul Workman,Wynne Aherne,Christopher J. Lord,Alan Ashworth +11 more
TL;DR: It is shown here, using an RNA interference (RNAi) approach, that inhibition of PPM1D can indeed reduce the viability of human tumour cells and that this effect is selective; tumour cell lines that overexpress P PM1D are sensitive to PPM 1D inhibition whereas cell lines with normal levels are not.
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LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells.
Peter Tamás,Andrew N. Macintyre,David K. Finlay,Rosemary G. Clarke,Carmen Feijoo-Carnero,Alan Ashworth,Doreen A. Cantrell +6 more
TL;DR: It is shown that loss of LKB1 prevents thymocyte differentiation and the production of peripheral T lymphocytes and reveals a conserved and essential role for L KB1 in the proliferative responses of both thymocytes and mature T cells.
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Complementation of byr1 in fission yeast by mammalian MAP kinase kinase requires coexpression of Raf kinase.
TL;DR: It is reported here that expression of mammalian MAP kinase kinase alone fails to complement a byr1 mutant of S. pombe, however, when coexpressed with Raf kinase, this suggests that the pathways are functionally homologous and that Raf Kinase may directly phosphorylate and activate MAP kin enzyme kinase.