A
Alan Ashworth
Researcher at University of California, San Francisco
Publications - 589
Citations - 82138
Alan Ashworth is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 134, co-authored 578 publications receiving 72089 citations. Previous affiliations of Alan Ashworth include Imperial College London & Papworth Hospital.
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Journal ArticleDOI
Microarray and histopathological analysis of tumours: the future and the past?
Sunil R. Lakhani,Alan Ashworth +1 more
TL;DR: The excitement surrounding the development of DNA microarray analysis and proteomics has raised questions about the role of these techniques in clinical practice and patient management, and how can high-throughput techniques contribute.
Journal ArticleDOI
Efficacy of Chemotherapy in BRCA1/2 Mutation Carrier Ovarian Cancer in the Setting of PARP Inhibitor Resistance: A Multi-Institutional Study
Joo Ern Ang,Charlie Gourley,C. Bethan Powell,Hilda High,Ronnie Shapira-Frommer,Vincent Castonguay,Jacques De Greve,T. Atkinson,Timothy A. Yap,Shahneen Sandhu,Susana Banerjee,Lee-may Chen,Michael Friedlander,Bella Kaufman,Amit M. Oza,Ursula A. Matulonis,Louise J. Barber,Iwanka Kozarewa,Kerry Fenwick,Ioannis Assiotis,James Campbell,Lina Chen,Johann S. de Bono,Martin Gore,Christopher J. Lord,Alan Ashworth,Stan B. Kaye +26 more
TL;DR: Heavily pretreated patients with BRCA1/2 mutation carrier ovarian cancer who are PARPi-resistant retain the potential to respond to subsequent chemotherapy, including platinum-based agents, according to a retrospective review of PBMCOC.
Posted ContentDOI
Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance
Stephen J. Pettitt,Dragomir B. Krastev,Inger Brandsma,Amy Dréan,Feifei Song,Radoslav Aleksandrov,Maria I. Harrell,Malini Menon,Rachel Brough,James Campbell,Jessica Frankum,Michael Ranes,Helen Pemberton,Rumana Rafiq,Kerry Fenwick,Amanda Swain,Sebastian Guettler,Jung-Min Lee,Elizabeth M. Swisher,Stoyno S. Stoynov,Kosuke Yusa,Alan Ashworth,Christopher J. Lord +22 more
TL;DR: Genome-wide and high-density CRISPR-Cas9 “tag, mutate and enrich” mutagenesis screens identified single amino acid mutations in PARP1 that cause profound PARPi-resistance and suggest that interactions between non-DNA binding domains ofPARP1 influence cytotoxicity.
Journal ArticleDOI
Mechanisms of Disease: angiogenesis and the management of breast cancer
TL;DR: The potential of various components of the angiogenic pathway as prognostic and predictive factors in breast cancer and the challenges facing the clinical development and optimum use of these agents are described.
Journal ArticleDOI
A candidate spermatogenesis gene on the mouse Y chromosome is homologous to ubiquitin-activating enzyme E1
Graham F. Kay,Alan Ashworth,Graeme D. Penny,Dunlop M,Sally Swift,Neil Brockdorff,Sohaila Rastan +6 more
TL;DR: The mouse Als9 gene is isolated, mapped it to the proximal portion of the X chromosome and shown that it undergoes normal X-inactivation, and is a candidate for the spermatogenesis gene, Spy, which maps to this region.