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Alan Ashworth
Researcher at University of California, San Francisco
Publications - 589
Citations - 82138
Alan Ashworth is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 134, co-authored 578 publications receiving 72089 citations. Previous affiliations of Alan Ashworth include Imperial College London & Papworth Hospital.
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Brca2 and Trp53 Deficiency Cooperate in the Progression of Mouse Prostate Tumourigenesis
TL;DR: Evidence is provided that Brca2 can act as a tumour suppressor in the prostate, and the model it is described should prove useful in the development of new therapeutic approaches.
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Phenotypic effects of heterozygosity for a BRCA2 mutation
TL;DR: It is demonstrated that, in a specific vertebrate cell type, the chicken B cell line DT40, heterozygosity for a BRCA2 mutation has a distinct phenotype, characterized by a reduced growth rate, increased cell death, heightened sensitivity to specific DNA damaging agents and reduced RAD51 focus formation after irradiation.
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Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors
Anja Rudolph,Roger L. Milne,Roger L. Milne,Thérèse Truong,Julia A. Knight,Julia A. Knight,Petra Seibold,Dieter Flesch-Janys,Sabine Behrens,Ursula Eilber,Manjeet K. Bolla,Qin Wang,Joe Dennis,Alison M. Dunning,Mitul Shah,Hannah Munday,Hatef Darabi,Mikael Eriksson,Judith S. Brand,Janet E. Olson,Celine M. Vachon,Emily Hallberg,J. Esteban Castelao,Angel Carracedo,Angel Carracedo,María Dolores Torres,Jingmei Li,Keith Humphreys,Emilie Cordina-Duverger,Florence Menegaux,Henrik Flyger,Børge G. Nordestgaard,Sune F. Nielsen,Betül T. Yesilyurt,Giuseppe Floris,Karin Leunen,Ellen G. Engelhardt,Annegien Broeks,Emiel J. Th. Rutgers,Gord Glendon,Anna Marie Mulligan,Anna Marie Mulligan,Simon S. Cross,Malcolm W.R. Reed,Anna González-Neira,Jose Ignacio Arias Perez,Elena Provenzano,Carmel Apicella,Melissa C. Southey,Amanda B. Spurdle,Lothar Häberle,Matthias W. Beckmann,Arif B. Ekici,A.K. Dieffenbach,Volker Arndt,Christa Stegmaier,Catriona McLean,Laura Baglietto,Laura Baglietto,Stephen J. Chanock,Jolanta Lissowska,Jolanta Lissowska,Mark E. Sherman,Thomas Brüning,Ute Hamann,Yon-Dschun Ko,Nick Orr,Minouk J. Schoemaker,Alan Ashworth,Veli-Matti Kosma,Vesa Kataja,Jaana M. Hartikainen,Arto Mannermaa,Anthony J. Swerdlow,Graham G. Giles,Hermann Brenner,Hermann Brenner,Peter A. Fasching,Peter A. Fasching,Georgia Chenevix-Trench,Georgia Chenevix-Trench,John L. Hopper,Javier Benitez,Angela Cox,Irene L. Andrulis,Irene L. Andrulis,Diether Lambrechts,Manuela Gago-Dominguez,Fergus J. Couch,Kamila Czene,Stig E. Bojesen,Doug Easton,Marjanka K. Schmidt,Pascal Guénel,Per Hall,Paul D.P. Pharoah,Montserrat Garcia-Closas,Jenny Chang-Claude +97 more
TL;DR: In conclusion, recently identified BC susceptibility loci are not strongly modified by established risk factors and the observed potential interactions require confirmation in independent studies.
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FXY2/MID2, a Gene Related to the X-Linked Opitz Syndrome Gene FXY/MID1, Maps to Xq22 and Encodes a FNIII Domain-Containing Protein That Associates with Microtubules
TL;DR: It is shown that the FXY2 protein similarly associates with microtubules in a manner that is dependent on the carboxy-terminal B30.2 domain, and this has implications for understanding protein function.
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The threonine residues in MAP kinase kinase 1 phosphorylated by MAP kinase in vitro are also phosphorylated in nerve growth factor-stimulated rat phaeochromocytoma (PC12) cells.
Yuji Saito,Néstor Gómez,David G. Campbell,Alan Ashworth,Christopher J. Marshall,Philip Cohen +5 more
TL;DR: The results establish that MAPKK1 is a physiological substrate for MAP kinase, demonstrating that neither species is the MAPKK2 isoform which lacks Thr‐291.