A
Alan Ashworth
Researcher at University of California, San Francisco
Publications - 589
Citations - 82138
Alan Ashworth is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 134, co-authored 578 publications receiving 72089 citations. Previous affiliations of Alan Ashworth include Imperial College London & Papworth Hospital.
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Journal ArticleDOI
Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells
Ilirjana Bajrami,Asha Kigozi,Antoinette van Weverwijk,Rachel Brough,Jessica Frankum,Christopher J. Lord,Alan Ashworth +6 more
TL;DR: The combination of a NAMPT small molecule inhibitor, FK866, with olaparib inhibited TN breast tumour growth in vivo to a greater extent than either single agent alone suggesting that assessing NAMpt/PARP inhibitor combinations for the treatment of TN breast cancer may be warranted.
Journal ArticleDOI
Fine-Scale Mapping of the FGFR2 Breast Cancer Risk Locus : Putative Functional Variants Differentially Bind FOXA1 and E2F1
Kerstin B. Meyer,Martin O'Reilly,Kyriaki Michailidou,Saskia Carlebur,Stacey L. Edwards,Stacey L. Edwards,Juliet D. French,Juliet D. French,Radhika Prathalingham,Joe Dennis,Manjeet K. Bolla,Qin Wang,Ines de Santiago,John L. Hopper,Helen Tsimiklis,Carmel Apicella,Melissa C. Southey,Marjanka K. Schmidt,Annegien Broeks,Laura J. van't Veer,Frans B. L. Hogervorst,Kenneth Muir,Kenneth Muir,Artitaya Lophatananon,Sarah Stewart-Brown,Pornthep Siriwanarangsan,Peter A. Fasching,Peter A. Fasching,Michael P. Lux,Arif B. Ekici,Matthias W. Beckmann,Julian Peto,Isabel dos Santos Silva,Olivia Fletcher,Nichola Johnson,Elinor J. Sawyer,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Federick Marme,Andreas Schneeweiss,Christof Sohn,Barbara Burwinkel,Barbara Burwinkel,Pascal Guénel,Thérèse Truong,Pierre Laurent-Puig,Florence Menegaux,Stig E. Bojesen,Børge G. Nordestgaard,Sune F. Nielsen,Henrik Flyger,Roger L. Milne,M. Pilar Zamora,José Ignacio Arias,Javier Benitez,Susan L. Neuhausen,Hoda Anton-Culver,Argyrios Ziogas,Christina Clarke Dur,Hermann Brenner,Heiko Müller,Volker Arndt,Christa Stegmaier,Alfons Meindl,Rita K. Schmutzler,Christoph Engel,Nina Ditsch,Hiltrud Brauch,Hiltrud Brauch,Thomas Brüning,Yon Ko,Heli Nevanlinna,Taru A. Muranen,Kristiina Aittomäki,Carl Blomqvist,Keitaro Matsuo,Hidemi Ito,Hiroji Iwata,Yasushi Yatabe,Thilo Dörk,Sonja Helbig,Natalia Bogdanova,Annika Lindblom,Sara Margolin,Arto Mannermaa,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Georgia Chenevix-Trench,Anna H. Wu,Chiu-Chen Tseng,David Van Den Berg,Daniel O. Stram,Diether Lambrechts,Diether Lambrechts,Bernard Thienpont,Bernard Thienpont,Marie Rose Christiaens,Ann Smeets,Jenny Chang-Claude,Anja Rudolph,Petra Seibold,Dieter Flesch-Janys,Paolo Radice,Paolo Peterlongo,Bernardo Bonanni,Loris Bernard,Fergus J. Couch,Janet E. Olson,Xianshu Wang,Kristen S. Purrington,Graham G. Giles,Graham G. Giles,Gianluca Severi,Gianluca Severi,Laura Baglietto,Catriona McLean,Christopher A. Haiman,Brian E. Henderson,Fredrick R. Schumacher,Loic Le Marchand,Jacques Simard,Mark S. Goldberg,Martine Dumont,Soo Hwang Teo,Cheng Har Yip,Sze Yee Phuah,Vessela N. Kristensen,Grethe I. Grenaker Alnæs,Anne Lise Børresen-Dale,Wei Zheng,Sandra Deming-Halverson,Martha J. Shrubsole,Jirong Long,Robert Winqvist,Katri Pylkäs,Arja Jukkola-Vuorinen,Saila Kauppila,Irene L. Andrulis,Julia A. Knight,Gord Glendon,Sandrine Tchatchou,Peter Devilee,Robert A.E.M. Tollenaar,Caroline M. Seynaeve,Montserrat Garcia-Closas,Jonine D. Figueroa,Stephen J. Chanock,Jolanta Lissowska,Kamila Czene,Hartef Darabi,Kimael Eriksson,Maartje J. Hooning,John W.M. Martens,Ans M.W. van den Ouweland,Carolien H.M. van Deurzen,Per Hall,Jingmei Li,Jianjun Liu,Keith Humphreys,Xiao-Ou Shu,Wei Lu,Yu Tang Gao,Hui Cai,Angela Cox,Malcolm W.R. Reed,William Blot,William Blot,Lisa B. Signorello,Qiuyin Cai,Paul D.P. Pharoah,Maya Ghoussaini,Patricia Harrington,Jonathan Tyrer,Daehee Kang,Ji Yeob Choi,Sue K. Park,Dong Young Noh,Mikael Hartman,Mikael Hartman,Miao Hui,Miao Hui,Wei-Yen Lim,Wei-Yen Lim,Shaik Ahmad Buhari,Ute Hamann,Asta Försti,Thomas Rüdiger,Hans Ulrich Ulmer,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska,Katarzyna Jaworska,Katarzyna Durda,Suleeporn Sangrajrang,Valerie Gaborieau,Paul Brennan,James McKay,Celine M. Vachon,Susan L. Slager,Florentia Fostira,Robert Pilarski,Chen-Yang Shen,Chen-Yang Shen,Chia-Ni Hsiung,Pei Ei Wu,Ming-Feng Hou,Anthony J. Swerdlow,Anthony J. Swerdlow,Alan Ashworth,Nick Orr,Minouk J. Schoemaker,Bruce A.J. Ponder,Alison M. Dunning,Douglas F. Easton +215 more
TL;DR: A role for FOXA1 in mediating breast cancer susceptibility at this locus is consistent with the finding that the FGFR2 risk locus primarily predisposes to estrogen-receptor-positive disease.
Journal ArticleDOI
Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation
Maya Ghoussaini,Stacey L. Edwards,Stacey L. Edwards,Kyriaki Michailidou,Silje Nord,Richard Cowper-Sal-lari,Kinjal Desai,Kinjal Desai,Siddhartha Kar,Kristine M. Hillman,Kristine M. Hillman,Susanne Kaufmann,Susanne Kaufmann,Dylan M. Glubb,Jonathan Beesley,Joe Dennis,Manjeet K. Bolla,Qin Wang,Ed Dicks,Qi Guo,Marjanka K. Schmidt,Mitul Shah,Robert Luben,Judith E. Brown,Kamila Czene,Hatef Darabi,Mikael Eriksson,Daniel Klevebring,Stig E. Bojesen,Børge G. Nordestgaard,Sune F. Nielsen,Henrik Flyger,Diether Lambrechts,Diether Lambrechts,Bernard Thienpont,Bernard Thienpont,Patrick Neven,Hans Wildiers,Annegien Broeks,Laura J. van't Veer,Emiel J. Th. Rutgers,Fergus J. Couch,Janet E. Olson,Emily Hallberg,Celine M. Vachon,Jenny Chang-Claude,Anja Rudolph,Petra Seibold,Dieter Flesch-Janys,Julian Peto,Isabel dos-Santos-Silva,Lorna Gibson,Heli Nevanlinna,Taru A. Muranen,Kristiina Aittomäki,Carl Blomqvist,Per Hall,Jingmei Li,Jianjun Liu,Keith Humphreys,Daehee Kang,Ji Yeob Choi,Sue K. Park,Dong-Young Noh,Keitaro Matsuo,Hidemi Ito,Hiroji Iwata,Yasushi Yatabe,Pascal Guénel,Pascal Guénel,Thérèse Truong,Thérèse Truong,Florence Menegaux,Florence Menegaux,Marie Sanchez,Marie Sanchez,Barbara Burwinkel,Barbara Burwinkel,Frederik Marmé,Andreas Schneeweiss,Christof Sohn,Anna H. Wu,Chiu-Chen Tseng,David Van Den Berg,Daniel O. Stram,Javier Benitez,M. Pilar Zamora,Jose Ignacio Arias Perez,Primitiva Menéndez,Xiao-Ou Shu,Wei Lu,Yu-Tang Gao,Qiuyin Cai,Angela Cox,Simon S. Cross,Malcolm W.R. Reed,Irene L. Andrulis,Julia A. Knight,Gord Glendon,Sandrine Tchatchou,Elinor J. Sawyer,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Christopher A. Haiman,Brian E. Henderson,Fredrick R. Schumacher,Loic Le Marchand,Annika Lindblom,Sara Margolin,Soo Hwang Teo,Cheng Har Yip,Daphne S.C. Lee,Tien Yin Wong,Maartje J. Hooning,John W.M. Martens,J. Margriet Collée,Carolien H.M. van Deurzen,John L. Hopper,Melissa C. Southey,Helen Tsimiklis,Miroslav Kapuscinski,Chen-Yang Shen,Chen-Yang Shen,Pei Ei Wu,Jyh Cherng Yu,Shou Tung Chen,Grethe I. Grenaker Alnæs,Anne Lise Børresen-Dale,Graham G. Giles,Graham G. Giles,Roger L. Milne,Roger L. Milne,Catriona McLean,Kenneth Muir,Kenneth Muir,Artitaya Lophatananon,Sarah Stewart-Brown,Pornthep Siriwanarangsan,Mikael Hartman,Mikael Hartman,Hui Miao,Shaik Ahmad Buhari,Yik Ying Teo,Yik Ying Teo,Peter A. Fasching,Lothar Haeberle,Arif B. Ekici,Matthias W. Beckmann,Hermann Brenner,Aida Karina Dieffenbach,Volker Arndt,Christa Stegmaier,Anthony J. Swerdlow,Alan Ashworth,Nick Orr,Minouk J. Schoemaker,Montserrat Garcia-Closas,Jonine D. Figueroa,Stephen J. Chanock,Jolanta Lissowska,Jacques Simard,Mark S. Goldberg,Martine Dumont,Robert Winqvist,Katri Pylkäs,Arja Jukkola-Vuorinen,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Thomas Brüning,Yon Dschun Koto,Paolo Radice,Paolo Peterlongo,Bernardo Bonanni,Sara Volorio,Thilo Dörk,Natalia Bogdanova,Sonja Helbig,Arto Mannermaa,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Peter Devilee,Robert A.E.M. Tollenaar,Caroline Seynaeve,Christi J. van Asperen,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska-Bieniek,Katarzyna Durda,Susan L. Slager,Amanda E. Toland,Christine B. Ambrosone,Drakoulis Yannoukakos,Suleeporn Sangrajrang,Valerie Gaborieau,Paul Brennan,James McKay,Ute Hamann,Diana Torres,Diana Torres,Wei Zheng,Jirong Long,Hoda Anton-Culver,Susan L. Neuhausen,Craig Luccarini,Caroline Baynes,Shahana Ahmed,Mel Maranian,Catherine S. Healey,Anna González-Neira,Guillermo Pita,M. Rosario Alonso,Nuria Álvarez,Daniel Herrero,Daniel C. Tessier,Daniel Vincent,Francois Bacot,Ines de Santiago,Jason S. Carroll,Carlos Caldas,Melissa A. Brown,Mathieu Lupien,Mathieu Lupien,Vessela N. Kristensen,Paul D.P. Pharoah,Georgia Chenevix-Trench,Juliet D. French,Juliet D. French,Douglas F. Easton,Alison M. Dunning,Penny Webb,Penny Webb,Anna de Fazio,Anna de Fazio +235 more
TL;DR: Evidence suggests that the g-allele confers increased breast cancer susceptibility through relative downregulation of IGFBP5, a gene with known roles in breast cell biology, which is associated with oestrogen receptor positive (ER+) disease.
Journal ArticleDOI
Drug resistance caused by reversion mutation.
TL;DR: It is shown that this sensitivity can be reversed, and resistance to PARP inhibition can be acquired by deletion of a mutation in BRCA2, and a similar mechanism seems to be associated with carboplatin resistance in some BRCa2 mutation carriers with ovarian cancer.
Journal ArticleDOI
Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis
Karin van Veldhoven,Silvia Polidoro,Laura Baglietto,Gianluca Severi,Carlotta Sacerdote,Salvatore Panico,Amalia Mattiello,Domenico Palli,Giovanna Masala,Vittorio Krogh,Claudia Agnoli,Rosario Tumino,Graziella Frasca,Kirsty Flower,Edward Curry,Nick Orr,Katarzyna Tomczyk,Michael Jones,Alan Ashworth,Anthony J. Swerdlow,Marc Chadeau-Hyam,Eiliv Lund,Montserrat Garcia-Closas,Torkjel M. Sandanger,James M. Flanagan,Paolo Vineis +25 more
TL;DR: It is concluded that epigenome-wide hypomethylation of DNA from pre-diagnostic blood samples may be predictive of breast cancer risk and may thus be useful as a clinical biomarker.