Alan Ashworth

TL;DR: The results imply that clinical management of the daughter of a woman with bilateral breast cancer should depend on her CHEK2*1100delC carrier status, and other moderate penetrance breast cancer susceptibility alleles, together with family history data, will thus identify increasing numbers of women at potentially very high risk.

TL;DR: This is the first time a carcinoma has been shown to harbour a duplication of the ETV6–NTRK3 translocation and the presence of an additional copy of the derivative chromosome der(15)t(12;15) coupled with deletion of the other derivative der(12)t (12; 15) in the modal population of cancer cells suggests that this was either an early phenomenon or conferred additional growth advantage on neoplastic cells.

TL;DR: These findings provide strong circumstantial evidence to suggest that acral melanoma cell lines and acral tumours share genetic features in common and that these cells are therefore valuable tools to investigate the biology of this aggressive melanoma subtype.

TL;DR: Now that there is overwhelming evidence that ZFY and TDF are distinct loci, the authors are left with a large body of data, and a question: what do these genes really do?

TL;DR: This study provides an insight into the mutational landscape of OGJ adenocarcinomas and confirms that this is a highly mutated and heterogeneous disease, and uncovered somatic mutations in therapeutically relevant genes which may represent candidate drug targets.