Alexias Safi

TL;DR: The Encyclopedia of DNA Elements project provides new insights into the organization and regulation of the authors' genes and genome, and is an expansive resource of functional annotations for biomedical research.

TL;DR: The first extensive map of human DHSs identified through genome-wide profiling in 125 diverse cell and tissue types is presented, revealing novel relationships between chromatin accessibility, transcription, DNA methylation and regulatory factor occupancy patterns.

TL;DR: These results demonstrate that repression mediated by dCas9-KRAB is sufficiently specific to disrupt the activity of individual enhancers via local modification of the epigenome.

TL;DR: A transcriptome- wide association study integrating genome-wide association data with expression data from brain, blood and adipose tissues identifies new candidate susceptibility genes for schizophrenia, providing a step toward understanding the underlying biology.

TL;DR: CRISPR–Cas9-based epigenomic regulatory element screening (CERES) is described for improved high-throughput screening of regulatory element activity in the native genomic context and allows the high-Throughput functional annotation of putative regulatory elements in their native chromosomal context.