James Gilbert

TL;DR: The Encyclopedia of DNA Elements project provides new insights into the organization and regulation of the authors' genes and genome, and is an expansive resource of functional annotations for biomedical research.

TL;DR: It is shown that the development of cystitis-induced bladder dysfunction is strongly impaired in Trpv4−/− mice, and HC-067047 is described, a previously uncharacterized, potent, and selective TRPV4 antagonist that increases functional bladder capacity and reduces micturition frequency in WT mice and rats with Cystitis.

TL;DR: This review article focuses on the major genes and signaling pathways implicated in ASD and discusses the cellular, molecular and functional studies that have shed light on common dysregulated pathways using in vitro, in vivo and human evidence.

TL;DR: In this article, the E3 ubiquitin ligase neural precursor cell (Nedd4) was shown to be responsible for AMPAR ubiquitination, leading to reduced AMPAR surface expression and suppressed excitatory synaptic transmission.

TL;DR: In cultured hippocampal neurons, it is reported that when activity of an individual presynaptic terminal is selectively elevated by light-controlled excitation, AMPAR abundance at the excited synapses is selectively downregulated in an NMDAR-dependent manner, indicating that AMPAR accumulation at individual synapse is subject to autonomous homeostatic regulation in response to synaptic activity.