Youwen Qin

TL;DR: MGWAS analysis showed that patients with type 2 diabetes were characterized by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in various opportunistic pathogens, as well as an enrichment of other microbial functions conferring sulphate reduction and oxidative stress resistance.

TL;DR: The first metagenomic profiling study of CRC faecal microbiomes is presented to discover and validate microbial biomarkers in ethnically different cohorts, and to independently validate selected biomarkers using an affordable clinically relevant technology.

TL;DR: This is the first clinical demonstration of a profound and specific intra-individual modification of gut microbial composition by full metagenomic sequencing in morbidly obese patients with T2D, and a clear correlation exists of microbiome composition and gene function with an improvement in metabolic and inflammatory parameters.

TL;DR: HP colonization results in alterations of gastric microbiota and reduction in bacterial diversity, which could be restored by antibiotic treatment, which was weak in GC samples which tended to have lower bacterial diversity compared with other samples with similar HP levels.

TL;DR: A combination of genetics and dietary habits was shown to strongly shape the abundances of certain key bacterial members of the gut microbiota, and explain their genetic association, and this work identifies putative causal relationships between gut microbes and complex diseases using MR.