C
Christian Datz
Researcher at University of Salzburg
Publications - 36
Citations - 3545
Christian Datz is an academic researcher from University of Salzburg. The author has contributed to research in topics: Cirrhosis & Alcoholic liver disease. The author has an hindex of 18, co-authored 36 publications receiving 2466 citations. Previous affiliations of Christian Datz include University of Düsseldorf & University of Erlangen-Nuremberg.
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Journal ArticleDOI
Gut microbiome development along the colorectal adenoma-carcinoma sequence.
Qiang Feng,Suisha Liang,Huijue Jia,Andreas Stadlmayr,Longqing Tang,Zhou Lan,Dongya Zhang,Huihua Xia,Xiaoying Xu,Zhuye Jie,Lili Su,Xiaoping Li,Xin Li,Junhua Li,Liang Xiao,Ursula Huber-Schönauer,David Niederseer,Xun Xu,Jumana Y. Al-Aama,Huanming Yang,Jian Wang,Karsten Kristiansen,Manimozhiyan Arumugam,Herbert Tilg,Christian Datz,Jun Wang +25 more
TL;DR: It is suggested that faecal microbiome-based strategies may be useful for early diagnosis and treatment of colorectal adenoma or carcinoma and high intake of red meat relative to fruits and vegetables appears to associate with outgrowth of bacteria that might contribute to a more hostile gut environment.
Journal ArticleDOI
Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer
Jun Yu,Qiang Feng,Sunny H. Wong,Dongya Zhang,Qiaoyi Liang,Youwen Qin,Longqing Tang,Hui Zhao,Jan Stenvang,Yanli Li,Xiaokai Wang,Xiaoqiang Xu,Ning Chen,William K.K. Wu,Jumana Y. Al-Aama,Hans Jørgen Nielsen,Pia Kiilerich,Benjamin A. H. Jensen,Tung On Yau,Zhou Lan,Huijue Jia,Junhua Li,Liang Xiao,Thomas Y.T. Lam,Siew C. Ng,Alfred S. L. Cheng,Vincent Wai-Sun Wong,Francis K.L. Chan,Xun Xu,Huanming Yang,Lise Madsen,Lise Madsen,Christian Datz,Herbert Tilg,Jian Wang,Nils Brünner,Karsten Kristiansen,Manimozhiyan Arumugam,Joseph J.Y. Sung,Jun Wang +39 more
TL;DR: The first metagenomic profiling study of CRC faecal microbiomes is presented to discover and validate microbial biomarkers in ethnically different cohorts, and to independently validate selected biomarkers using an affordable clinically relevant technology.
Journal ArticleDOI
A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis
Stephan Buch,Felix Stickel,Eric Trepo,Michael J. Way,A Herrmann,Hans Dieter Nischalke,Mario Brosch,Jonas Rosendahl,Thomas Berg,Monika Ridinger,Marcella Rietschel,Andrew McQuillin,Josef Frank,Falk Kiefer,Stefan Schreiber,Wolfgang Lieb,Michael Soyka,Nasser Semmo,Elmar Aigner,Christian Datz,Renate Schmelz,Stefan Brückner,Sebastian Zeissig,Anna-Magdalena Stephan,Norbert Wodarz,Jacques Devière,Nicolas Clumeck,Christoph Sarrazin,Frank Lammert,Thierry Gustot,Pierre Deltenre,Pierre Deltenre,Henry Völzke,Markus M. Lerch,Julia Mayerle,Florian Eyer,Clemens Schafmayer,Sven Cichon,Markus M. Nöthen,Michael Nothnagel,David Ellinghaus,Klaus Huse,Andre Franke,Steffen Zopf,Claus Hellerbrand,Christophe Moreno,Denis Franchimont,Marsha Y. Morgan,Jochen Hampe +48 more
TL;DR: A genome-wide association study for alcohol-related cirrhosis in individuals of European descent with subsequent validation in two independent European cohorts is performed, suggesting that lipid turnover is important in the pathogenesis of alcohol- related Cirrhosis.
Journal ArticleDOI
Gut microbiome development along the colorectal adenoma-carcinoma sequence
Andreas Stadlmayr,Qiang Feng,Ursula Huber-Schönauer,David Niederseer,Elmar Aigner,Jun Wang,Herbert Tilg,Christian Datz +7 more
Journal ArticleDOI
Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians
Felix Stickel,Stephan Buch,Katharina Lau,Henriette E. Meyer zu Schwabedissen,Thomas Berg,Monika Ridinger,Marcella Rietschel,Clemens Schafmayer,Felix Braun,Holger Hinrichsen,Rainer Günther,Alexander Arlt,Marcus Seeger,Sebastian Müller,Helmut K. Seitz,Michael Soyka,Markus M. Lerch,Frank Lammert,Christoph Sarrazin,Ralf Kubitz,Dieter Häussinger,C Hellerbrand,D Bröring,Stefan Schreiber,Falk Kiefer,Rainer Spanagel,Karl Mann,Christian Datz,Michael Krawczak,Norbert Wodarz,Henry Völzke,Jochen Hampe +31 more
TL;DR: Genotype PNPLA3 rs738409(GG) is associated with alcoholic liver cirrhosis and elevated aminotransferase levels in alcoholic Caucasians.