A
Allan Bradley
Researcher at Wellcome Trust Sanger Institute
Publications - 385
Citations - 81969
Allan Bradley is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 127, co-authored 379 publications receiving 77492 citations. Previous affiliations of Allan Bradley include Howard Hughes Medical Institute & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Lawrence A. Donehower,Michele Harvey,Betty L. Slagle,Mark J. McArthur,Charles A. Montgomery,Janet S. Butel,Allan Bradley +6 more
TL;DR: Observations indicate that a normal p53 gene is dispensable for embryonic development, that its absence predisposes the animal to neoplastic disease, and that an oncogenic mutant form of p53 is not obligatory for the genesis of many types of tumours.
Journal ArticleDOI
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
TL;DR: It is demonstrated that src is not required for general cell viability (possibly because of functional overlap with other tyrosine kinases related to src) and an essential role for src in bone formation is uncovered.
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Identification of Mammalian microRNA Host Genes and Transcription Units
TL;DR: It is strongly suggested that miRNAs are transcribed in parallel with their host transcripts, and that the two different transcription classes of miRNAAs ('exonic' and 'intronic') identified here may require slightly different mechanisms of biogenesis.
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p63 is a p53 homologue required for limb and epidermal morphogenesis.
TL;DR: P63 is essential for several aspects of ectodermal differentiation during embryogenesis, including hair follicles, teeth and mammary glands, which are absent in p63-deficient mice.
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Requirement of bic/microRNA-155 for normal immune function.
Antony Rodriguez,Elena Vigorito,Simon Clare,Madhuri Warren,Madhuri Warren,Philippe Couttet,Dalya R. Soond,Stijn van Dongen,Russell J. Grocock,Partha Pratim Das,Eric A. Miska,David Vetrie,Klaus Okkenhaug,Anton J. Enright,Gordon Dougan,Martin R Turner,Allan Bradley +16 more
TL;DR: It is shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling, and suggests that bic-micro RNA-155 plays a key role in the homeostasis and function of the immune system.