A
Amanda B. Muir
Researcher at Children's Hospital of Philadelphia
Publications - 104
Citations - 2587
Amanda B. Muir is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Eosinophilic esophagitis & Medicine. The author has an hindex of 21, co-authored 74 publications receiving 1641 citations. Previous affiliations of Amanda B. Muir include University of Pennsylvania.
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Journal ArticleDOI
Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference.
Evan S. Dellon,Chris A. Liacouras,Javier Molina-Infante,Glenn T. Furuta,Jonathan M. Spergel,Noam Zevit,Stuart J. Spechler,Stephen Attwood,Alex Straumann,Seema S. Aceves,Jeffrey A. Alexander,Dan Atkins,Nicoleta C. Arva,Carine Blanchard,Peter A Bonis,Wendy Book,Kelley E. Capocelli,Mirna Chehade,Edaire Cheng,Margaret H. Collins,Carla M. Davis,Jorge Amil Dias,Carlo Di Lorenzo,Ranjan Dohil,Christophe Dupont,Gary W. Falk,Cristina Targa Ferreira,Adam T. Fox,Nirmala Gonsalves,Sandeep K. Gupta,David A. Katzka,Yoshikazu Kinoshita,Calies Menard-Katcher,Ellyn Kodroff,David C. Metz,Stephan Miehlke,Amanda B. Muir,Vincent A. Mukkada,Simon Murch,Samuel Nurko,Yoshikazu Ohtsuka,Rok Orel,Alexandra Papadopoulou,Kathryn A. Peterson,Hamish Philpott,Philip E. Putnam,Joel E. Richter,Rachel Rosen,Marc E. Rothenberg,Alain M. Schoepfer,Melissa Scott,Neil Shah,Javed Sheikh,Rhonda F. Souza,Mary Jo Strobel,Nicholas J. Talley,Michael F. Vaezi,Yvan Vandenplas,Mario C. Vieira,Marjorie M. Walker,Joshua B. Wechsler,Barry K. Wershil,Ting Wen,Guang Yu Yang,Ikuo Hirano,Albert J. Bredenoord +65 more
TL;DR: An updated diagnostic algorithm for EoE was developed, with removal of the PPI trial requirement, and the evidence suggests that PPIs are better classified as a treatment for esophageal eosinophilia that may be due to EOE than as a diagnostic criterion.
Journal ArticleDOI
Thymic stromal lymphopoietin–elicited basophil responses promote eosinophilic esophagitis
Mario Noti,Elia D. Tait Wojno,Brian S. Kim,Mark C. Siracusa,Paul R. Giacomin,Paul R. Giacomin,Meera G. Nair,Meera G. Nair,Alain Benitez,Kathryn Ruymann,Amanda B. Muir,David A. Hill,Kudakwashe R. Chikwava,Amin E. Moghaddam,Quentin J. Sattentau,Aneesh Alex,Chao Zhou,Jennifer H. Yearley,Paul Menard-Katcher,Masato Kubo,Kazushige Obata-Ninomiya,Hajime Karasuyama,Michael R. Comeau,Terri F. Brown-Whitehorn,Rene De Waal Malefyt,Patrick M. A. Sleiman,Hakon Hakonarson,Antonella Cianferoni,Gary W. Falk,Mei Lun Wang,Jonathan M. Spergel,David Artis +31 more
TL;DR: A new mouse model of EoE-like disease that developed independently of IgE, but was dependent on TSLP and basophils is described, suggesting that the T SLP-basophil axis contributes to the pathogenesis of EeE and could be therapeutically targeted to treat this disease.
Journal ArticleDOI
Inflammation-associated microbiota in pediatric eosinophilic esophagitis
Alain Benitez,Christian Hoffmann,Christian Hoffmann,Amanda B. Muir,Amanda B. Muir,Kara K. Dods,Jonathan M. Spergel,Jonathan M. Spergel,Frederic D. Bushman,Mei-Lun Wang,Mei-Lun Wang +10 more
TL;DR: The esophageal microbiome in EoE is distinct from that of non-EoE controls, with maximal differences observed during active allergic inflammation, and targeted therapeutic dietary intervention may influence community structure.
Journal ArticleDOI
Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells.
Takashi Kijima,Hiroshi Nakagawa,Masataka Shimonosono,Prasanna M. Chandramouleeswaran,Takeo Hara,Varun Sahu,Yuta Kasagi,Osamu Kikuchi,Koji Tanaka,Veronique Giroux,Amanda B. Muir,Kelly A. Whelan,Shinya Ohashi,Seiji Naganuma,Andres J. Klein-Szanto,Yoshiaki Shinden,Ken Sasaki,Itaru Omoto,Yoshiaki Kita,Manabu Muto,Adam J. Bass,J. Alan Diehl,Gregory G. Ginsberg,Yuichiro Doki,Masaki Mori,Yasuto Uchikado,Takaaki Arigami,Narayan G. Avadhani,Devraj Basu,Anil K. Rustgi,Shoji Natsugoe +30 more
TL;DR: The single cell-based 3D organoid system may serve as a highly efficient platform to explore cancer therapeutics and therapy resistance mechanisms in conjunction with morphological and functional assays with implications for translation in personalized medicine.
Journal ArticleDOI
Increasing Rates of Diagnosis, Substantial Co-Occurrence, and Variable Treatment Patterns of Eosinophilic Gastritis, Gastroenteritis, and Colitis Based on 10-Year Data Across a Multicenter Consortium.
Robert D. Pesek,Craig C. Reed,Amanda B. Muir,Patricia C. Fulkerson,Calies Menard-Katcher,Gary W. Falk,Jonathan Kuhl,Ellen K Martin,Adam Z. Magier,Faria N. Ahmed,Maureen DeMarshall,Ankur Gupta,Jonathan Gross,Tokunbo Ashorobi,Christina L Carpenter,Jeffrey P. Krischer,Nirmala Gonsalves,Jonathan M. Spergel,Sandeep K. Gupta,Glenn T. Furuta,Marc E. Rothenberg,Evan S. Dellon +21 more
TL;DR: In this cohort, EG, EGE, and EC were diagnosed more frequently over time, and inflammation of GI segments outside the primary disease site co-occurrence of atopy was common with a lack of male predominance.