J
Joshua B. Wechsler
Researcher at Children's Memorial Hospital
Publications - 71
Citations - 2699
Joshua B. Wechsler is an academic researcher from Children's Memorial Hospital. The author has contributed to research in topics: Eosinophilic esophagitis & Medicine. The author has an hindex of 18, co-authored 45 publications receiving 1924 citations. Previous affiliations of Joshua B. Wechsler include Northwestern University & University of Chicago.
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Journal ArticleDOI
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome.
Joshua B. Wechsler,Marianne E. Greene,Michael A. McDevitt,John Anastasi,Judith E. Karp,Michelle M. Le Beau,John D. Crispino +6 more
TL;DR: It is shown that leukemic cells from every individual with DS-AMKL contain mutations in GATA1, encoding the essential hematopoietic transcription factor Gata1 (GATA binding protein 1 or globin transcription factor 1), and that loss of wildtype GATA 1 constitutes one step in the pathogenesis of AMKL in Down syndrome.
Journal ArticleDOI
Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference.
Evan S. Dellon,Chris A. Liacouras,Javier Molina-Infante,Glenn T. Furuta,Jonathan M. Spergel,Noam Zevit,Stuart J. Spechler,Stephen Attwood,Alex Straumann,Seema S. Aceves,Jeffrey A. Alexander,Dan Atkins,Nicoleta C. Arva,Carine Blanchard,Peter A Bonis,Wendy Book,Kelley E. Capocelli,Mirna Chehade,Edaire Cheng,Margaret H. Collins,Carla M. Davis,Jorge Amil Dias,Carlo Di Lorenzo,Ranjan Dohil,Christophe Dupont,Gary W. Falk,Cristina Targa Ferreira,Adam T. Fox,Nirmala Gonsalves,Sandeep K. Gupta,David A. Katzka,Yoshikazu Kinoshita,Calies Menard-Katcher,Ellyn Kodroff,David C. Metz,Stephan Miehlke,Amanda B. Muir,Vincent A. Mukkada,Simon Murch,Samuel Nurko,Yoshikazu Ohtsuka,Rok Orel,Alexandra Papadopoulou,Kathryn A. Peterson,Hamish Philpott,Philip E. Putnam,Joel E. Richter,Rachel Rosen,Marc E. Rothenberg,Alain M. Schoepfer,Melissa Scott,Neil Shah,Javed Sheikh,Rhonda F. Souza,Mary Jo Strobel,Nicholas J. Talley,Michael F. Vaezi,Yvan Vandenplas,Mario C. Vieira,Marjorie M. Walker,Joshua B. Wechsler,Barry K. Wershil,Ting Wen,Guang Yu Yang,Ikuo Hirano,Albert J. Bredenoord +65 more
TL;DR: An updated diagnostic algorithm for EoE was developed, with removal of the PPI trial requirement, and the evidence suggests that PPIs are better classified as a treatment for esophageal eosinophilia that may be due to EOE than as a diagnostic criterion.
Journal ArticleDOI
Post-Infectious Functional Gastrointestinal Disorders in Children
Miguel Saps,Licia Pensabene,Lucio Di Martino,Annamaria Staiano,Joshua B. Wechsler,Xiaotian Zheng,Carlo Di Lorenzo +6 more
TL;DR: There is a significant increase in cases of FGIDs after bacterial infections in children, particularly after an episode of acute bacterial gastroenteritis in children.
Journal ArticleDOI
Efficacy of a 4-Food Elimination Diet for Children With Eosinophilic Esophagitis
Amir F. Kagalwalla,Amir F. Kagalwalla,Joshua B. Wechsler,Katie Amsden,Sally Schwartz,Melanie M. Makhija,Anthony Olive,Carla M. Davis,Maria Manuel-Rubio,Seth B Marcus,Ronda Shaykin,Maureen Sulkowski,Kristen Johnson,Jessica Ross,Mary Ellen Riffle,Marion Groetch,Hector Melin-Aldana,Deborah Schady,Hannah L. Palac,Kwan Youn A. Kim,Barry K. Wershil,Barry K. Wershil,Margaret H. Collins,Mirna Chehade +23 more
TL;DR: 8 weeks of 4‐food elimination diet induced clinical, endoscopic, and histologic remission in more than 60% of children with EoE, and can be recommended as a treatment for children withEoE.
Journal ArticleDOI
Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome
Jeffrey W. Taub,Gina Mundschau,Yubin Ge,Janet Poulik,Faisal Qureshi,Tanya L. Jensen,S. Jill James,Larry H. Matherly,Joshua B. Wechsler,John D. Crispino +9 more
TL;DR: Somatic mutations in exon 2 of the transcription factor GATA1 gene have been detected in essentially all Down syndrome (DS) megakaryocytic leukemia (AMkL) and transient myeloproliferative disorder (TMD) cases.