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Anand Swaroop
Researcher at National Institutes of Health
Publications - 528
Citations - 53580
Anand Swaroop is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Retinitis pigmentosa & Retinal degeneration. The author has an hindex of 89, co-authored 508 publications receiving 43170 citations. Previous affiliations of Anand Swaroop include Vision-Sciences, Inc. & Yale University.
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Journal ArticleDOI
Deletion of Aryl Hydrocarbon Receptor AHR in Mice Leads to Subretinal Accumulation of Microglia and RPE Atrophy
Soo-Young Kim,Hyun-Jin Yang,Yi Sheng Chang,Jung-Woong Kim,Matthew Brooks,Emily Y. Chew,Wai T. Wong,Robert N. Fariss,Rivka A. Rachel,Tiziana Cogliati,Haohua Qian,Anand Swaroop +11 more
TL;DR: This study suggests that AHR has a protective role in the retina as an environmental stress sensor and its altered function may contribute to human AMD progression and provide a target for pharmacological intervention.
Journal ArticleDOI
Human retinopathy-associated ciliary protein retinitis pigmentosa GTPase regulator mediates cilia-dependent vertebrate development
Amiya K. Ghosh,Carlos Murga-Zamalloa,Lansze Chan,Peter F. Hitchcock,Anand Swaroop,Hemant Khanna +5 more
TL;DR: It is proposed that RPGR is involved in cilia-dependent cascades during development in zebrafish and provided evidence for a heterogenic effect of the disease-causing mutations on the function of RPGR.
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Pluripotent stem cell-derived retinal organoids for disease modeling and development of therapies.
Kamil Kruczek,Anand Swaroop +1 more
TL;DR: The current status and future potential of combining retinal organoids as human models with recent technologies to advance the development of gene, cell, and drug therapies for retinopathies are discussed.
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Next generation sequencing technology and genomewide data analysis: Perspectives for retinal research
Vijender Chaitankar,Gökhan Karakülah,Rinki Ratnapriya,Felipe O. Giuste,Matthew Brooks,Anand Swaroop +5 more
TL;DR: The basic design of commonly used NGS-based methods, specifically whole exome sequencing, transcriptome, and epigenome profiling are illustrated, and recommendations for data analyses are provided.
Journal ArticleDOI
Analysis of the RPGR gene in 11 pedigrees with the retinitis pigmentosa type 3 genotype: paucity of mutations in the coding region but splice defects in two families.
Ricardo Fujita,M. Buraczynska,Linn Gieser,Weiping Wu,Patricia Forsythe,Magnus Abrahamson,Samuel G. Jacobson,Paul A. Sieving,Sten Andréasson,Anand Swaroop +9 more
TL;DR: The hypothesis that mutations in the reported RPGR gene are not a common defect in the RP3 subtype of XLRP and that a majority of causative mutations may reside either in as yet unidentified RPGR exons or in another nearby gene at Xp21.1 is supported.