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Anand Swaroop
Researcher at National Institutes of Health
Publications - 528
Citations - 53580
Anand Swaroop is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Retinitis pigmentosa & Retinal degeneration. The author has an hindex of 89, co-authored 508 publications receiving 43170 citations. Previous affiliations of Anand Swaroop include Vision-Sciences, Inc. & Yale University.
Papers
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Journal Article
An optimized protocol for retina single-cell RNA sequencing.
Benjamin R. Fadl,Seth A. Brodie,Michael Malasky,Joseph Boland,Michael C. Kelly,Matthew W. Kelley,Erich T. Boger,Robert N. Fariss,Anand Swaroop,Laura Campello +9 more
TL;DR: A gentle method for dissociation of the mouse retina that minimizes cell death and preserves cell morphology is reported and results in detection of higher transcriptional complexity and better-quality single-cell RNA-sequencing data in retina samples.
Journal ArticleDOI
Clinical studies of X-linked retinitis pigmentosa in three Swedish families with newly identified mutations in the RP2 and RPGR-ORF15 genes
Sten Andréasson,Debra K. Breuer,Louise Eksandh,Vesna Ponjavic,Christina Frennesson,Suja Hiriyanna,E. Filippova,Beverly M. Yashar,Anand Swaroop +8 more
TL;DR: New disease-causing RP2 and RPGR-ORF15 mutations and their corresponding clinical phenotypes in Swedish families with X-linked retinitis pigmentosa (XLRP) are described and genotype-phenotype correlations are established by studying the clinical spectrum of disease in families with a known molecular defect.
Journal ArticleDOI
Retinal disease in ciliopathies: Recent advances with a focus on stem cell-based therapies
TL;DR: The biology of photoreceptor cilia and associated defects are reviewed and recent progress in evolving treatment modalities, especially using patient-derived iPSCs, for retinal ciliopathies are discussed.
Book ChapterDOI
Retinal transcriptome profiling by directional next-generation sequencing using 100 ng of total RNA.
TL;DR: A detailed protocol is described for the creation of a directional RNA-seq library from 100 ng of starting total RNA if one starts with low amount of RNA and obtains transcript directionality during the analysis.
Journal ArticleDOI
Natural history of cone disease in the murine model of Leber congenital amaurosis due to CEP290 mutation: determining the timing and expectation of therapy.
Shannon E. Boye,Wei Chieh Huang,Alejandro J. Roman,Alexander Sumaroka,Sanford L. Boye,Renee C. Ryals,Melani B. Olivares,Qing Ruan,Budd A. Tucker,Edwin M. Stone,Anand Swaroop,Artur V. Cideciyan,William W. Hauswirth,Samuel G. Jacobson +13 more
TL;DR: The natural history of early loss of photoreceptor function with retained cone cell nuclei is common to both CEP290-LCA patients and the rd16;Nrl−/− murine model, and pre-clinical proof-of-concept studies for uniocular therapies would seem most appropriate.