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Anand Swaroop
Researcher at National Institutes of Health
Publications - 528
Citations - 53580
Anand Swaroop is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Retinitis pigmentosa & Retinal degeneration. The author has an hindex of 89, co-authored 508 publications receiving 43170 citations. Previous affiliations of Anand Swaroop include Vision-Sciences, Inc. & Yale University.
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Journal ArticleDOI
Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors.
Masayuki Akimoto,Hong Cheng,Dongxiao Zhu,Joseph A. Brzezinski,Ritu Khanna,E. Filippova,Edwin C. Oh,Yuezhou Jing,Jose Luis Linares,Matthew Brooks,Sepideh Zareparsi,Alan J. Mears,Alan J. Mears,Alfred O. Hero,Thomas M Glaser,Anand Swaroop +15 more
TL;DR: The Maf-family transcription factor Nrl is a key regulator of photoreceptor differentiation in mammals and it is shown that a 2.5-kb Nrl promoter segment directs the expression of enhanced GFP specifically to rod photoreceptors and the pineal gland of transgenic mice.
Journal ArticleDOI
Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration.
TL;DR: Current findings on the genetics of AMD are discussed to highlight areas of rapid progress and new challenges and it is attempted to integrate available genetic and biochemical data with cellular pathways involved in aging to formulate an integrated model of AMD pathogenesis.
Journal ArticleDOI
A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies.
Hemant Khanna,Erica E. Davis,Carlos Murga-Zamalloa,Alejandro Estrada-Cuzcano,Irma Lopez,Anneke I. den Hollander,Marijke N. Zonneveld,Mohammad Othman,Naushin Waseem,Christina Chakarova,Cécilia Maubaret,Anna Diaz-Font,Ian M. MacDonald,Donna M. Muzny,David A. Wheeler,Margaret Morgan,Lora Lewis,Clare V. Logan,Perciliz L. Tan,Michael A. Beer,Chris F. Inglehearn,Richard A. Lewis,Samuel G. Jacobson,Carsten Bergmann,Philip L. Beales,Tania Attié-Bitach,Colin A. Johnson,Edgar A. Otto,Shomi S. Bhattacharya,Friedhelm Hildebrandt,Richard A. Gibbs,Robert K. Koenekoop,Anand Swaroop,Anand Swaroop,Nicholas Katsanis +34 more
TL;DR: It is demonstrated that a polymorphic coding variant of RPGRIP1L (retinitis pigmentosa GTPase regulator-interacting protein-1 like), a ciliary gene mutated in Meckel-Gruber and Joubert syndromes, is associated with the development of retinal degeneration in individuals with ciliopathies caused by mutations in other genes.
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Mutations in the Cone-Rod Homeobox Gene Are Associated with the Cone-Rod Dystrophy Photoreceptor Degeneration
Prabodha K. Swain,Shiming Chen,Qing Liang Wang,Louisa M. Affatigato,Caraline L. Coats,Kevin D. Brady,Gerald A. Fishman,Samuel G. Jacobson,Anand Swaroop,Edwin M. Stone,Paul A. Sieving,Donald J. Zack +11 more
TL;DR: The data suggests that mutations in the CRX gene are associated with photoreceptor degeneration and that the Crx protein is necessary for the maintenance of normal cone and rod function.
Journal ArticleDOI
Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa
William A. Beltran,Artur V. Cideciyan,Alfred S. Lewin,Simone Iwabe,Hemant Khanna,Alexander Sumaroka,Vince A. Chiodo,Diego Fajardo,Alejandro J. Roman,Wen-Tao Deng,Malgorzata Swider,Tomas S. Aleman,Sanford L. Boye,Sem Genini,Anand Swaroop,William W. Hauswirth,Samuel G. Jacobson,Gustavo D. Aguirre +17 more
TL;DR: Efficacy of gene therapy in two blinding canine photoreceptor diseases that model the common X-linked form of retinitis pigmentosa provides a path for translation to human treatment.