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Anand Swaroop
Researcher at National Institutes of Health
Publications - 528
Citations - 53580
Anand Swaroop is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Retinitis pigmentosa & Retinal degeneration. The author has an hindex of 89, co-authored 508 publications receiving 43170 citations. Previous affiliations of Anand Swaroop include Vision-Sciences, Inc. & Yale University.
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Journal ArticleDOI
Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation
Wenxin Ma,Radu Cojocaru,Norimoto Gotoh,Linn Gieser,Rafael Villasmil,Tiziana Cogliati,Anand Swaroop,Wai T. Wong +7 more
TL;DR: Senescent microglia demonstrate age-related gene expression changes capable of altering their constitutive support functions and regulation of their activation status in ways relating to neuroinflammation and neurodegeneration in the CNS.
Journal Article
Three-dimensional retinal organoids from mouse pluripotent stem cells mimic in vivo development with enhanced stratification and rod photoreceptor differentiation.
TL;DR: 3D retinal organoids, generated by the HIPRO method, closely mimic in vivo retinogenesis and provide an efficient in vitro model to investigate photoreceptor development and modeling disease pathology.
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A simple and efficient cDNA library subtraction procedure: isolation of human retina-specific cDNA clones
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Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesis.
Rivka A. Rachel,Helen May-Simera,Shobi Veleri,Norimoto Gotoh,Byung Yoon Choi,Byung Yoon Choi,Carlos Murga-Zamalloa,Jeremy C. McIntyre,Jonah E. Marek,Irma Lopez,Alice N. Hackett,Matthew Brooks,Anneke I. den Hollander,Philip L. Beales,Tiansen Li,Samuel G. Jacobson,Raman Sood,Jeffrey R. Martens,Paul P. Liu,Thomas B. Friedman,Hemant Khanna,Hemant Khanna,Robert K. Koenekoop,Matthew W. Kelley,Anand Swaroop +24 more
TL;DR: It is proposed that altered association of CEP290 and MKKS affects the integrity of multiprotein complexes at the cilia transition zone and basal body and suggests a possible novel approach for treating human ciliopathies.
Journal ArticleDOI
Conditional knockdown of DNA methyltransferase 1 reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesis
Igor O. Nasonkin,Shannath L. Merbs,Kevin Lazo,Verity F. Oliver,Matthew Brooks,Krushangi Patel,Ray Enke,Jacob Nellissery,Milan Jamrich,Yun Z. Le,Kapil Bharti,Robert N. Fariss,Rivka A. Rachel,Donald J. Zack,Enrique Rodriguez-Boulan,Anand Swaroop +15 more
TL;DR: A unique function of DNMT1-mediated DNA methylation in controlling RPE apicobasal polarity and neural retina differentiation is demonstrated and a model to study the epigenetic mechanisms and signaling pathways that guide the modulation of photoreceptor outer segment morphogenesis by RPE during retinal development and disease is established.