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Anand Swaroop
Researcher at National Institutes of Health
Publications - 528
Citations - 53580
Anand Swaroop is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Retinitis pigmentosa & Retinal degeneration. The author has an hindex of 89, co-authored 508 publications receiving 43170 citations. Previous affiliations of Anand Swaroop include Vision-Sciences, Inc. & Yale University.
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Journal ArticleDOI
Mutation in a short-chain collagen gene, CTRP5, results in extracellular deposit formation in late-onset retinal degeneration - a genetic model for age-related macular degeneration
Caroline Hayward,Xinhua Shu,Artur V. Cideciyan,Alan Lennon,Perdita E. Barran,Sepideh Zareparsi,Lindsay Sawyer,Grace Hendry,Baljean Dhillon,Ann H. Milam,Philip J. Luthert,Anand Swaroop,Nicholas D. Hastie,Samuel G. Jacobson,Alan F. Wright +14 more
TL;DR: It is shown that L-ORD is genetically heterogeneous and that a proposed founder mutation in the CTRP5 (C1QTNF5) gene, which encodes a novel short-chain collagen, changes a highly conserved serine to arginine (Ser163Arg) in 7/14 L-ord families and 0/1000 control individuals.
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Expression profiling of the developing and mature Nrl−/− mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl
Shigeo Yoshida,Alan J. Mears,Alan J. Mears,James S. Friedman,Todd A. Carter,Shirley He,Edwin C. Oh,Yuezhou Jing,Rafal Farjo,Rafal Farjo,Gilles Fleury,Carrolee Barlow,Carrolee Barlow,Alfred O. Hero,Anand Swaroop +14 more
TL;DR: These studies provide molecular insights into differences between rod and cone function, yield interesting candidates for retinal diseases and assist in identifying transcriptional regulatory targets of Nrl.
Journal ArticleDOI
Identification of a rare coding variant in complement 3 associated with age-related macular degeneration
Xiaowei Zhan,David E. Larson,Chaolong Wang,Chaolong Wang,Daniel C. Koboldt,Yuri V. Sergeev,Robert S. Fulton,Lucinda Fulton,Catrina Fronick,Kari Branham,Jennifer L. Bragg-Gresham,Goo Jun,Youna Hu,Hyun Min Kang,Dajiang J. Liu,Mohammad Othman,Matthew Brooks,Rinki Ratnapriya,Alexis Boleda,Felix Grassmann,Claudia N von Strachwitz,Lana M. Olson,Gabriëlle H.S. Buitendijk,Albert Hofman,Cornelia M. van Duijn,Valentina Cipriani,Valentina Cipriani,Anthony T. Moore,Anthony T. Moore,Humma Shahid,Humma Shahid,Yingda Jiang,Yvette P. Conley,Denise J. Morgan,Ivana K. Kim,Matthew P. Johnson,Stuart Cantsilieris,Andrea J. Richardson,Robyn H. Guymer,Hongrong Luo,Hong Ouyang,Christoph Licht,Fred G. Pluthero,Mindy M. Zhang,Kang Zhang,Paul N. Baird,John Blangero,Michael L. Klein,Lindsay A. Farrer,Margaret M. DeAngelis,Daniel E. Weeks,Michael B. Gorin,John R.W. Yates,John R.W. Yates,John R.W. Yates,Caroline C W Klaver,Margaret A. Pericak-Vance,Jonathan L. Haines,Bernhard H. F. Weber,Richard K. Wilson,John R. Heckenlively,Emily Y. Chew,Dwight Stambolian,Elaine R. Mardis,Anand Swaroop,Gonçalo R. Abecasis +65 more
TL;DR: Two large-effect rare coding variants associated with a large increase in risk of age-related macular degeneration suggest decreased inhibition of C3 by complement factor H, resulting in increased activation of the alternative complement pathway, as a key component of disease biology.
Journal ArticleDOI
Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL
TL;DR: It is established that NRL is not only essential but is sufficient for rod differentiation and that postmitotic photoreceptor precursors are competent to make binary decisions during early retinogenesis.
Journal ArticleDOI
RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins.
Hemant Khanna,Toby W. Hurd,Concepción Lillo,Xinhua Shu,Sunil K. Parapuram,Shirley He,Masayuki Akimoto,Alan F. Wright,Ben Margolis,David S. Williams,Anand Swaroop +10 more
TL;DR: Novel evidence is provided for the possible involvement of RPGR-ORF15 in microtubule organization and regulation of transport in primary cilia in retinitis pigmentosa through interaction with SMC1 and SMC3.