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Anand Swaroop
Researcher at National Institutes of Health
Publications - 528
Citations - 53580
Anand Swaroop is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Retinitis pigmentosa & Retinal degeneration. The author has an hindex of 89, co-authored 508 publications receiving 43170 citations. Previous affiliations of Anand Swaroop include Vision-Sciences, Inc. & Yale University.
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Journal ArticleDOI
Development and Plasticity of Outer Retinal Circuitry Following Genetic Removal of Horizontal Cells
Patrick W. Keeley,Gabriel Luna,Robert N. Fariss,Kimberly A. Skyles,Nils R. Madsen,Mary A. Raven,Ross A. Poché,Eric C. Swindell,Milan Jamrich,Edwin C. Oh,Anand Swaroop,Steven K. Fisher,Benjamin E. Reese +12 more
TL;DR: The results demonstrate the critical yet distinctive roles for horizontal cells on the rod and cone pathways and highlight a unique and as-yet-unrecognized maintenance function of an inhibitory interneuron that is not required for the initial targeting and co-stratification of other components in the circuit.
Journal ArticleDOI
Madeline 2.0 PDE
Edward H. Trager,Ritu Khanna,Adrian Marrs,Lawrence Siden,Kari Branham,Anand Swaroop,Julia E. Richards +6 more
TL;DR: The Madeline 2.0 Pedigree Drawing Engine (PDE) is a pedigree drawing program for use in linkage and family-based association studies, designed to handle large and complex pedigrees with an emphasis on readability and aesthetics.
Journal ArticleDOI
De novo mutation in the RP1 gene (Arg677ter) associated with retinitis pigmentosa.
Sharon B. Schwartz,Tomas S. Aleman,Artur V. Cideciyan,Anand Swaroop,Samuel G. Jacobson,Edwin M. Stone +5 more
TL;DR: The de novo origin of an RP1 (Arg677ter) mutation in a patient with simplex RP suggests that this common autosomal dominant RP mutation can arise independently in the population and supports the hypothesis of a mutational hotspot in the RP1 gene.
Journal ArticleDOI
Treatment Paradigms for Retinal and Macular Diseases Using 3-D Retina Cultures Derived From Human Reporter Pluripotent Stem Cell Lines.
Rossukon Kaewkhaw,Rossukon Kaewkhaw,Manju Swaroop,Kohei Homma,Jutaro Nakamura,Matthew Brooks,Koray Dogan Kaya,Vijender Chaitankar,Sam Michael,Gregory J. Tawa,Jizhong Zou,Mahendra Rao,Wei Zheng,Tiziana Cogliati,Anand Swaroop +14 more
TL;DR: The use of pluripotent stem cell lines carrying fluorescent reporters driven by retinal promoters to derive three-dimensional retina in culture is discussed and how this system can be exploited for elucidating human retinal biology, creating disease models in a dish, and designing targeted drug screens for retinal and macular degeneration.
Journal ArticleDOI
Combinatorial regulation of photoreceptor differentiation factor, neural retina leucine zipper gene NRL, revealed by in vivo promoter analysis.
TL;DR: The studies demonstrate Nrl as a direct transcriptional target of RORβ and suggest that combinatorial action of multiple regulatory factors modulates the expression of Nrl in developing and mature retina.