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Anand Swaroop
Researcher at National Institutes of Health
Publications - 528
Citations - 53580
Anand Swaroop is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Retinitis pigmentosa & Retinal degeneration. The author has an hindex of 89, co-authored 508 publications receiving 43170 citations. Previous affiliations of Anand Swaroop include Vision-Sciences, Inc. & Yale University.
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Journal ArticleDOI
Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits.
TL;DR: Genome-wide association and re-sequencing projects, together with gene-environment interaction studies, are expected to further define the causal relationships that connect genetic variants to AMD pathogenesis and should assist in better design of prevention and intervention.
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Leber Congenital Amaurosis Caused by a Homozygous Mutation (R90W) in the Homeodomain of the Retinal Transcription Factor CRX: Direct Evidence for the Involvement of CRX in the Development of Photoreceptor Function
Anand Swaroop,Qing Liang Wang,Weiping Wu,Jason Cook,Caraline L. Coats,Siqun Xu,Shiming Chen,Donald J. Zack,Paul A. Sieving +8 more
TL;DR: Data suggest that the R90W mutation results in a CRX protein with reduced DNA binding and transcriptional regulatory activity and that the subsequent changes in photoreceptor gene expression lead to the very early onset severe visual impairment in LCA.
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Age-Related Macular Degeneration: A High-Resolution Genome Scan for Susceptibility Loci in a Population Enriched for Late-Stage Disease
Gonçalo R. Abecasis,Beverly M. Yashar,Yu Zhao,Noor M. Ghiasvand,Noor M. Ghiasvand,Sepideh Zareparsi,Kari Branham,Adam C. Reddick,Edward H. Trager,Shigeo Yoshida,John Bahling,E. Filippova,Susan G. Elner,Mark W. Johnson,Andrew K. Vine,Paul A. Sieving,Paul A. Sieving,Samuel G. Jacobson,Julia E. Richards,Anand Swaroop +19 more
TL;DR: The results consolidate the chromosomal locations of several AMD susceptibility loci and, together with previous reports, should facilitate the search for disease-associated sequence variants.
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Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration
Rinki Ratnapriya,Olukayode A. Sosina,Olukayode A. Sosina,Margaret R. Starostik,Madeline Kwicklis,Rebecca J. Kapphahn,Lars G. Fritsche,Ashley Walton,Marios Arvanitis,Linn Gieser,Alexandra Pietraszkiewicz,Sandra R. Montezuma,Emily Y. Chew,Alexis Battle,Gonçalo R. Abecasis,Deborah A. Ferrington,Nilanjan Chatterjee,Anand Swaroop +17 more
TL;DR: Three additional genes, RLBP1, HIC1 and PARP12, after Bonferroni correction are identified and the Eye Genotype Expression database is established as a resource for post-GWAS interpretation of multifactorial ocular traits.
Journal ArticleDOI
Molecular Anatomy of the Developing Human Retina
Akina Hoshino,Rinki Ratnapriya,Matthew Brooks,Vijender Chaitankar,Matthew S. Wilken,Chi Zhang,Margaret R. Starostik,Linn Gieser,Anna La Torre,Anna La Torre,Mario Nishio,Olivia Bates,Ashley Walton,Olivia Bermingham-McDonogh,Ian A. Glass,Rachel O.L. Wong,Anand Swaroop,Thomas A. Reh +17 more
TL;DR: Three key epochs are defined in the transcriptome dynamics of human retina from fetal day (D) 52 to 136 to confirm the cellular basis of transcriptional changes and highlight the dramatic acceleration of development in the fovea compared with peripheral retina.