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Andrew D. Yates
Researcher at European Bioinformatics Institute
Publications - 49
Citations - 11538
Andrew D. Yates is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Ensembl & Ensembl Genomes. The author has an hindex of 22, co-authored 44 publications receiving 8619 citations. Previous affiliations of Andrew D. Yates include Novartis Institute for Tropical Diseases & Wellcome Trust.
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Journal ArticleDOI
Patterns of somatic mutation in human cancer genomes
Christopher Greenman,Philip J. Stephens,Raffaella Smith,Gillian L. Dalgliesh,Christopher I. Hunter,Graham R. Bignell,Helen Davies,Jon W. Teague,Adam Butler,Claire Stevens,Sarah Edkins,Sarah O’Meara,Imre Vastrik,Esther Schmidt,Tim Avis,Syd Barthorpe,Gurpreet Bhamra,Gemma Buck,Bhudipa Choudhury,Jody Clements,Jennifer Cole,Ed Dicks,Simon A. Forbes,Kris Gray,Kelly Halliday,Rachel Harrison,Katy Hills,Jon Hinton,Andy Jenkinson,David T. Jones,Andy Menzies,Tatiana Mironenko,Janet Perry,Keiran Raine,Dave Richardson,Rebecca Shepherd,Alexandra Small,Calli Tofts,Jennifer Varian,Tony Webb,Sofie West,Sara Widaa,Andrew D. Yates,Daniel P. Cahill,David N. Louis,Peter Goldstraw,Andrew G. Nicholson,Francis Brasseur,Leendert H. J. Looijenga,Barbara L. Weber,Yoke Eng Chiew,Anna deFazio,Mel Greaves,Anthony R. Green,Peter J. Campbell,Ewan Birney,Douglas F. Easton,Georgia Chenevix-Trench,Min-Han Tan,Sok Kean Khoo,Bin Tean Teh,Siu Tsan Yuen,Suet Yi Leung,Richard Wooster,P. Andrew Futreal,Michael R. Stratton,Michael R. Stratton +66 more
TL;DR: More than 1,000 somatic mutations found in 274 megabases of DNA corresponding to the coding exons of 518 protein kinase genes in 210 diverse human cancers reveal the evolutionary diversity of cancers and implicates a larger repertoire of cancer genes than previously anticipated.
Journal ArticleDOI
GENCODE reference annotation for the human and mouse genomes.
Adam Frankish,Mark Diekhans,Anne-Maud Ferreira,Rory Johnson,Irwin Jungreis,Irwin Jungreis,Jane E. Loveland,Jonathan M. Mudge,Cristina Sisu,Cristina Sisu,James C. Wright,Joel Armstrong,If Barnes,Andrew Berry,Alexandra Bignell,Silvia Carbonell Sala,Jacqueline Chrast,Fiona Cunningham,Tomás Di Domenico,Sarah Donaldson,Ian T. Fiddes,Carlos García Girón,Jose Manuel Gonzalez,Tiago Grego,Matthew P. Hardy,Thibaut Hourlier,Toby Hunt,Osagie G. Izuogu,Julien Lagarde,Fergal J. Martin,Laura Martinez,Shamika Mohanan,Paul R. Muir,Fabio C. P. Navarro,Anne Parker,Baikang Pei,Fernando Pozo,Magali Ruffier,Bianca M. Schmitt,Eloise Stapleton,Marie-Marthe Suner,Irina Sycheva,Barbara Uszczynska-Ratajczak,Jinuri Xu,Andrew D. Yates,Daniel R. Zerbino,Yan Zhang,Yan Zhang,Bronwen Aken,Jyoti S. Choudhary,Mark Gerstein,Roderic Guigó,Tim Hubbard,Manolis Kellis,Manolis Kellis,Benedict Paten,Alexandre Reymond,Michael L. Tress,Paul Flicek +58 more
TL;DR: This work generates primary data, creates bioinformatics tools and provides analysis to support the work of expert manual gene annotators and automated gene annotation pipelines to identify and characterise gene loci to the highest standard.
Journal ArticleDOI
Lung cancer: intragenic ERBB2 kinase mutations in tumours.
Philip J. Stephens,Christopher I. Hunter,Graham R. Bignell,Sarah Edkins,Helen Davies,Jon W. Teague,Claire Stevens,Sarah O’Meara,Raffaella Smith,Adrian Parker,Andy Barthorpe,Matthew J. Blow,Lisa Brackenbury,Adam Butler,Oliver Clarke,Jennifer Cole,Ed Dicks,Angus Dike,Anja Drozd,Ken Edwards,Simon A. Forbes,Rebecca Foster,Kristian Gray,Christopher Greenman,Kelly Halliday,Katy Hills,Vivienne Kosmidou,Richard Lugg,Andy Menzies,Janet Perry,Robert Petty,Keiran Raine,Lewis Ratford,Rebecca Shepherd,Alexandra Small,Yvonne Stephens,Calli Tofts,Jennifer Varian,Sofie West,Sara Widaa,Andrew D. Yates,Francis Brasseur,Colin Cooper,Adrienne M. Flanagan,Margaret A. Knowles,Suet Yi Leung,David N. Louis,Leendert H. J. Looijenga,Bruce Malkowicz,Marco A. Pierotti,Bin Teh,Georgia Chenevix-Trench,Barbara L. Weber,Siu Tsan Yuen,Grace Harris,Peter Goldstraw,Andrew G. Nicholson,P. Andrew Futreal,Richard Wooster,Michael R. Stratton,Michael R. Stratton +60 more
TL;DR: The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promising targets for the design of antitumour therapies as mentioned in this paper.
Journal Article
Ensembl 2021
Kevin L. Howe,P. Achuthan,Jamie Allen,Jorge Alvarez-Jarreta,M. R. Amode,Irina M. Armean,A. G. Azov,Ruth Bennett,Jyothish Bhai,Konstantinos Billis,Sanjay Boddu,M. Charkhchi,Carla Cummins,L. Da Rin Fioretto,Claire Davidson,K. Dodiya,B. El Houdaigui,R. Fatima,Astrid Gall,C. Garcia Giron,Tiago Grego,C. Guijarro-Clarke,Leanne Haggerty,A. Hemrom,Thibaut Hourlier,Osagie G. Izuogu,Thomas Juettemann,V. Kaikala,M. Kay,Ilias Lavidas,T. Le,Diana Lemos,J. Gonzalez Martinez,J. C. Marugán,Thomas Maurel,Aoife McMahon,S. Mohanan,Benjamin Moore,Matthieu Muffato,D. N. Oheh,D. Paraschas,Anne Parker,Andrew Parton,I. Prosovetskaia,Manoj Pandian Sakthivel,A. I. A. Salam,Bianca M. Schmitt,Helen Schuilenburg,Dan Sheppard,E. Steed,Michal Szpak,M. Szuba,Kieron Taylor,Anja Thormann,Glen Threadgold,Brandon Walts,Andrea Winterbottom,Marc Chakiachvili,A. Chaubal,N. De Silva,B. Flint,Adam Frankish,Sarah E. Hunt,Gr, I. Isley, Langridge, N.,Jane E. Loveland,Fergal J. Martin,Jonathan M. Mudge,Joannella Morales,Emily Perry,Magali Ruffier,John Tate,David Thybert,Stephen J. Trevanion,Fiona Cunningham,Andrew D. Yates,Daniel R. Zerbino,Paul Flicek +76 more
TL;DR: Recent Ensembl developments are presented including two new website portals, which are designed to provide core tools and services for genomes as soon as possible and has been deployed to support large biodiversity sequencing projects.
Journal ArticleDOI
Somatic Mutations of the Protein Kinase Gene Family in Human Lung Cancer
Helen Davies,Christopher I. Hunter,Raffaella Smith,Philip J. Stephens,Christopher Greenman,Graham R. Bignell,Jon W. Teague,Adam Butler,Sarah Edkins,Claire Stevens,Adrian Parker,Sarah O’Meara,Tim Avis,Syd Barthorpe,Lisa Brackenbury,Gemma Buck,Jody Clements,Jennifer Cole,Ed Dicks,Ken Edwards,Simon A. Forbes,Matthew Gorton,Kristian Gray,Kelly Halliday,Rachel Harrison,Katy Hills,Jonathon Hinton,David Jones,Vivienne Kosmidou,Ross Laman,Richard Lugg,Andrew Menzies,Janet Perry,Robert Petty,Keiran Raine,Rebecca Shepherd,Alexandra Small,Helen Solomon,Yvonne Stephens,Calli Tofts,Jennifer Varian,Anthony Webb,Sofie West,Sara Widaa,Andrew D. Yates,Francis Brasseur,Colin Cooper,Adrienne M. Flanagan,Anthony R. Green,Maggie Knowles,Suet Yi Leung,Leendert H. J. Looijenga,Bruce Malkowicz,Marco A. Pierotti,Bin Tean Teh,Siu Tsan Yuen,Sunil R. Lakhani,Douglas F. Easton,Barbara L. Weber,Peter Goldstraw,Andrew G. Nicholson,Richard Wooster,Richard Wooster,Michael R. Stratton,P. Andrew Futreal +64 more
TL;DR: The results suggest that several mutated protein kinases may be contributing to lung cancer development, but that mutations in each one are infrequent.