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Anil Chandraker
Researcher at Brigham and Women's Hospital
Publications - 225
Citations - 11075
Anil Chandraker is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Transplantation & Kidney transplantation. The author has an hindex of 51, co-authored 215 publications receiving 9892 citations. Previous affiliations of Anil Chandraker include Lahey Hospital & Medical Center & National Institutes of Health.
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Journal ArticleDOI
Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
Elisabeth M. Zeisberg,Oleg Tarnavski,Michael Zeisberg,Adam L. Dorfman,Julie R. McMullen,Erika Gustafsson,Anil Chandraker,Xueli Yuan,William T. Pu,Anita B. Roberts,Eric G. Neilson,Mohamed H. Sayegh,Seigo Izumo,Raghu Kalluri +13 more
TL;DR: It is shown that cardiac fibrosis is associated with the emergence of fibroblasts originating from endothelial cells, suggesting an endothelial-mesenchymal transition (EndMT) similar to events that occur during formation of the atrioventricular cushion in the embryonic heart.
Journal ArticleDOI
Effects of explosive brain death on cytokine activation of peripheral organs in the rat.
Moriatsu Takada,Kari C. Nadeau,Wayne W. Hancock,Harald S. Mackenzie,Gray D. Shaw,Ana Marie Waaga,Anil Chandraker,Mohamed H. Sayegh,Nicholas L. Tilney +8 more
TL;DR: It is hypothesized that irreversible central nervous system injury may up-regulate proinflammatory mediators and cell surface molecules in peripheral organs to be engrafted, making them more prone to host inflammatory and immunological responses.
Journal ArticleDOI
Extrathymic T Cell Deletion and Allogeneic Stem Cell Engraftment Induced with Costimulatory Blockade Is Followed by Central T Cell Tolerance
Thomas Wekerle,Mohamed H. Sayegh,Joshua Hill,Yong Zhao,Anil Chandraker,Kirsten G. Swenson,Guiling Zhao,Megan Sykes +7 more
TL;DR: It is shown that high levels of chimerism and systemic T cell tolerance can be reliably achieved without myeloablation or T cell depletion of the host.
Journal ArticleDOI
Role of the PD-1 Pathway in the Immune Response
TL;DR: The upregulation of PD‐L1 on nonhematopoietic cells of the allograft may actively participate in the inhibition of immune responses and provide tissue‐specific protection.
Journal ArticleDOI
The promise of organ and tissue preservation to transform medicine
Sebastian Giwa,Jedediah K. Lewis,Luis M. Alvarez,Luis M. Alvarez,Luis M. Alvarez,Robert Langer,Alvin E. Roth,George M. Church,James F. Markmann,David H. Sachs,Anil Chandraker,Anil Chandraker,Jason A. Wertheim,Martine Rothblatt,Edward S. Boyden,Elling Eidbo,W. P. Andrew Lee,Bohdan Pomahac,Gerald Brandacher,David M. Weinstock,Gloria D. Elliott,David R. Nelson,Jason P. Acker,Korkut Uygun,Boris Schmalz,Boris Schmalz,Brad P Weegman,Alessandro Tocchio,Greg M Fahy,Kenneth B. Storey,Boris Rubinsky,John C. Bischof,Janet A.W. Elliott,Teresa K. Woodruff,G. John Morris,Utkan Demirci,Kelvin G. M. Brockbank,Erik J. Woods,Robert N. Ben,John G. Baust,Dayong Gao,Barry Fuller,Yoed Rabin,David C. Kravitz,Michael J. Taylor,Michael J. Taylor,Mehmet Toner +46 more
TL;DR: Developments indicate that a new paradigm, integrating multiple existing preservation approaches and new technologies that have flourished in the past 10 years, could transform preservation research.