Jinrong Huang

TL;DR: A comprehensive molecular dissection of the main regions of the human, pig, and mouse brain using transcriptomics and antibody-based mapping suggests similar regional organization and expression patterns in the three mammalian species, consistent with the view that basic brain architecture is preserved during mammalian evolution.

TL;DR: NRF2 agonists 4-OI and DMF induce a distinct IFN-independent antiviral program that is broadly effective in limiting virus replication and in suppressing the pro-inflammatory responses of human pathogenic viruses, including SARS-CoV2.

TL;DR: The study indicates that gene editing is more efficient in euchromatin than in heterochromatin, and this finding is validated in HeLa cells and in human fibroblasts and the gRNA sequence determinants of CRISPR‐Cas9 activity are investigated using a surrogate reporter system and it is found that the efficiency of Cas9‐mediated gene edited is dependent on guide sequence secondary structure formation.

TL;DR: Signal transducer and activator of transcription-3 (STAT3) is identified as a key factor in the preservation of alkaline cytosol and regulator of STAT3 localization and activity as a regulator of intracellular pH.

TL;DR: It is proved that dCas9 methyltransferases cause efficient RNA-guided methylation of specific endogenous CpGs and can mediate transient inhibition of gene expression, which might be caused by d Cas9-mediated de novo DNA methylation as well as interference with transcription.