J
J. Kathleen Moch
Researcher at Walter Reed Army Institute of Research
Publications - 20
Citations - 4117
J. Kathleen Moch is an academic researcher from Walter Reed Army Institute of Research. The author has contributed to research in topics: Plasmodium falciparum & Apical membrane antigen 1. The author has an hindex of 18, co-authored 20 publications receiving 3910 citations. Previous affiliations of J. Kathleen Moch include Naval Medical Research Center & Henry M. Jackson Foundation for the Advancement of Military Medicine.
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Journal ArticleDOI
A proteomic view of the Plasmodium falciparum life cycle
Laurence Florens,Michael P. Washburn,J. Dale Raine,Robert M. Anthony,Munira Grainger,J. David Haynes,J. David Haynes,J. Kathleen Moch,Nemone Muster,John B. Sacci,John B. Sacci,David L. Tabb,David L. Tabb,Adam A. Witney,Adam A. Witney,Dirk Wolters,Dirk Wolters,Yimin Wu,Malcolm J. Gardner,Anthony A. Holder,Robert E. Sinden,John R. Yates,John R. Yates,Daniel J. Carucci +23 more
TL;DR: A high-throughput proteomics approach was applied to identify new potential drug and vaccine targets and to better understand the biology of this complex protozoan parasite.
Journal ArticleDOI
Discovery of Gene Function by Expression Profiling of the Malaria Parasite Life Cycle
Karine G. Le Roch,Yingyao Zhou,Peter L. Blair,Muni Grainger,J. Kathleen Moch,J. David Haynes,Patricia de la Vega,Anthony A. Holder,Serge Batalov,Daniel J. Carucci,Elizabeth A. Winzeler,Elizabeth A. Winzeler +11 more
TL;DR: A high-density oligonucleotide array is used to generate expression profiles of human and mosquito stages of the malaria parasite's life cycle and finds genes with highly correlated levels and temporal patterns of expression were often involved in similar functions or cellular processes.
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Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion
Prakash Srinivasan,Wandy L. Beatty,Ababacar Diouf,Raul Herrera,Xavier Ambroggio,J. Kathleen Moch,Jessica S. Tyler,David L. Narum,Susan K. Pierce,John C. Boothroyd,J. David Haynes,Louis H. Miller +11 more
TL;DR: Results identify the binding of RON2 to the hydrophobic pocket of AMA1 as the step that commits Plasmodium merozoites to RBC invasion and point to RON 2 as a potential vaccine candidate.
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Molecular Factors and Biochemical Pathways Induced by Febrile Temperature in Intraerythrocytic Plasmodium falciparum Parasites
Miranda S. Oakley,Miranda S. Oakley,Sanjai Kumar,Vivek Anantharaman,Hong Zheng,Babita Mahajan,J. David Haynes,J. Kathleen Moch,Rick M. Fairhurst,Thomas F. McCutchan,L. Aravind +10 more
TL;DR: The presence of the “crisis forms” and the terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling-positive parasites following heat treatment strongly support the notion that an apoptosis-like cell death mechanism might be induced in response to febrile temperatures.
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Protection of Aotus monkeys by Plasmodium falciparum EBA-175 region II DNA prime-protein boost immunization regimen.
Trevor R. Jones,David L. Narum,Alfonso S. Gozalo,Joao C. Aguiar,Steven R. Fuhrmann,Hong Liang,J. David Haynes,J. David Haynes,J. Kathleen Moch,J. Kathleen Moch,Carmen Lucas,Tin Luu,Alan J. Magill,Stephen L. Hoffman,Betty Kim Lee Sim +14 more
TL;DR: It is demonstrated that immunization with EBA-175 region II induces a significant antiparasite effect in vivo, and three of 4 monkeys in the Dv-Pv group did not require treatment.