Begüm Aydin

TL;DR: It is demonstrated that an HFD promotes tumour progression in the small intestine of genetically susceptible, K-rasG12Dint, mice independently of obesity, and this data underscore the importance of the reciprocal interaction between host and environmental factors in selecting a microbiota that favours carcinogenesis.

TL;DR: This analysis reveals a highly dynamic process in which Ngn2 and the Isl1/Lhx3 pair initially engage distinct regulatory regions, and motor neuron programming is the product of two initially independent transcriptional modules that converge with a feedforward transcriptional logic.

TL;DR: This study provides a mechanistic understanding of how transcription factors constrain terminal cell fates, and it delineates the importance of choosing the right proneural factor in neuronal reprogramming strategies.

TL;DR: A review of key studies that shed light on the cellular and molecular mechanisms by investigating differentiation trajectories and alternative cell states as well as transcription factor regulatory activities during cell fate reprogramming.

TL;DR: In this article, the authors investigated possible tolerance mechanisms preventing neuronal loss and disruption in gut motility after pathogen exposure, and found that following enteric infections, muscularis macrophages acquire a tissue-protective phenotype that prevents neuronal loss, dysmotility, and maintains energy balance during subsequent challenge with unrelated pathogens.