B
Begüm Aydin
Researcher at New York University
Publications - 12
Citations - 645
Begüm Aydin is an academic researcher from New York University. The author has contributed to research in topics: Transcription factor & Chromatin. The author has an hindex of 6, co-authored 11 publications receiving 430 citations. Previous affiliations of Begüm Aydin include Boğaziçi University & Rockefeller University.
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Journal ArticleDOI
High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity
Manon D. Schulz,Çiğdem Atay,Jessica Heringer,Franziska K. Romrig,Sarah Schwitalla,Begüm Aydin,Paul K. Ziegler,Julia Varga,W Reindl,Claudia Pommerenke,Gabriela Salinas-Riester,Andreas Böck,Carl Alpert,Michael Blaut,Sara C. Polson,Lydia Brandl,Thomas Kirchner,Florian R. Greten,Shawn W. Polson,Melek C. Arkan +19 more
TL;DR: It is demonstrated that an HFD promotes tumour progression in the small intestine of genetically susceptible, K-rasG12Dint, mice independently of obesity, and this data underscore the importance of the reciprocal interaction between host and environmental factors in selecting a microbiota that favours carcinogenesis.
Journal ArticleDOI
A multi-step transcriptional and chromatin state cascade underlies motor neuron programming from embryonic stem cells
Silvia Velasco,Mahmoud M. Ibrahim,Mahmoud M. Ibrahim,Akshay Kakumanu,Görkem Garipler,Begüm Aydin,Mohamed Al-Sayegh,Mohamed Al-Sayegh,Antje Hirsekorn,Farah Abdul-Rahman,Rahul Satija,Uwe Ohler,Uwe Ohler,Shaun Mahony,Esteban O. Mazzoni +14 more
TL;DR: This analysis reveals a highly dynamic process in which Ngn2 and the Isl1/Lhx3 pair initially engage distinct regulatory regions, and motor neuron programming is the product of two initially independent transcriptional modules that converge with a feedforward transcriptional logic.
Journal ArticleDOI
Proneural factors Ascl1 and Neurog2 contribute to neuronal subtype identities by establishing distinct chromatin landscapes
Begüm Aydin,Akshay Kakumanu,Mary Rossillo,Mireia Moreno-Estellés,Görkem Garipler,Niels Ringstad,Nuria Flames,Shaun Mahony,Esteban O. Mazzoni +8 more
TL;DR: This study provides a mechanistic understanding of how transcription factors constrain terminal cell fates, and it delineates the importance of choosing the right proneural factor in neuronal reprogramming strategies.
Journal ArticleDOI
Cell Reprogramming: The Many Roads to Success.
Begüm Aydin,Esteban O. Mazzoni +1 more
TL;DR: A review of key studies that shed light on the cellular and molecular mechanisms by investigating differentiation trajectories and alternative cell states as well as transcription factor regulatory activities during cell fate reprogramming.
Journal ArticleDOI
Enteric pathogens induce tissue tolerance and prevent neuronal loss from subsequent infections
Tomasz Ahrends,Begüm Aydin,Fanny Matheis,Cajsa H. Classon,François Marchildon,Glaucia C. Furtado,Sergio A. Lira,Daniel Mucida,Daniel Mucida +8 more
TL;DR: In this article, the authors investigated possible tolerance mechanisms preventing neuronal loss and disruption in gut motility after pathogen exposure, and found that following enteric infections, muscularis macrophages acquire a tissue-protective phenotype that prevents neuronal loss, dysmotility, and maintains energy balance during subsequent challenge with unrelated pathogens.