Blanca Estela Del Río-Navarro

TL;DR: The results suggest that some asthma susceptibility loci are robust to differences in ancestry when sufficiently large samples sizes are investigated, and that ancestry-specific associations also contribute to the complex genetic architecture of asthma.

TL;DR: In children with moderate and severe asthma, ozone levels 1 day before spirometry were inversely associated significantly with forced expiratory flow (FEF(25-75) and PEF), and supplementation with antioxidants might modulate the impact of ozone exposure on the small airways of children with severe asthma.

TL;DR: Analysis of genome-wide expression data in 51 human tissues from the Novartis Research Foundation showed that median GWAS significance levels for SNPs in genes expressed in the lung differed most significantly from genes not expressed inThe lung when compared to 50 other tissues, supporting the biological plausibility of the overall GWAS findings and the multigenic etiology of childhood asthma.

TL;DR: Among subjects with homozygous deletion of GSTM1, carriers of a serine allele were at significantly reduced risk of asthma compared with Pro/Pro homozygotes, consistent with a protective effect of the NQO1 Ser allele in this population of GST M1-null children with high ozone exposure.

TL;DR: It is suggested that SNPs in several candidate genes, including TGFB 1, IL1RL1, IL18R1, and DPP10, might contribute to childhood asthma susceptibility in a Mexican population.