G
Grace Y. Chiu
Researcher at Research Triangle Park
Publications - 7
Citations - 1243
Grace Y. Chiu is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Single-nucleotide polymorphism & Genome-wide association study. The author has an hindex of 6, co-authored 7 publications receiving 1162 citations. Previous affiliations of Grace Y. Chiu include Westat.
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Journal ArticleDOI
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations
Dara G. Torgerson,Dara G. Torgerson,Elizabeth J. Ampleford,Grace Y. Chiu,W. James Gauderman,Christopher R. Gignoux,Penelope E. Graves,Blanca E. Himes,Albert M. Levin,Rasika A. Mathias,Dana B. Hancock,Dana B. Hancock,Dana B. Hancock,James W. Baurley,Celeste Eng,Debra A. Stern,Juan C. Celedón,Nicholas Rafaels,Daniel Capurso,David V. Conti,Lindsey A. Roth,Manuel Soto-Quiros,Alkis Togias,Xingnan Li,Rachel A. Myers,Isabelle Romieu,Isabelle Romieu,David Van Den Berg,Donglei Hu,Nadia N. Hansel,Ryan D. Hernandez,Elliott Israel,Muhammad T. Salam,Joshua Galanter,Pedro C. Avila,Lydiana Avila,Jose R. Rodriquez-Santana,R. Chapela,William Rodríguez-Cintrón,Gregory B. Diette,N. Franklin Adkinson,Rebekah A. Abel,K. Ross,Min Shi,Mezbah U. Faruque,Georgia M. Dunston,Harold Watson,Vito J. Mantese,Serpil C. Ezurum,Liming Liang,Ingo Ruczinski,Jean G. Ford,Scott Huntsman,Kian Fan Chung,Hita Vora,Xia Li,William J. Calhoun,Mario Castro,Juan José Luis Sienra-Monge,Blanca Estela Del Río-Navarro,Klaus A. Deichmann,Andrea Heinzmann,Sally E. Wenzel,William W. Busse,William W. Busse,James E. Gern,Robert F. Lemanske,Terri H. Beaty,Eugene R. Bleecker,Benjamin A. Raby,Deborah A. Meyers,Stephanie J. London,Frank D. Gilliland,Esteban G. Burchard,Fernando D. Martinez,Scott T. Weiss,L. Keoki Williams,Kathleen C. Barnes,Carole Ober,Dan L. Nicolae +79 more
TL;DR: The results suggest that some asthma susceptibility loci are robust to differences in ancestry when sufficiently large samples sizes are investigated, and that ancestry-specific associations also contribute to the complex genetic architecture of asthma.
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Genome-Wide Association Study Implicates Chromosome 9q21.31 as a Susceptibility Locus for Asthma in Mexican Children
Dana B. Hancock,Isabelle Romieu,Min Shi,Juan José Luis Sienra-Monge,Hao Wu,Grace Y. Chiu,Huiling Li,Blanca Estela Del Río-Navarro,Saffron A.G. Willis-Owens,Scott T. Weiss,Benjamin A. Raby,Hong Gao,Celeste Eng,Rocio Chapela,Esteban G. Burchard,Hua Tang,Patrick F. Sullivan,Stephanie J. London +17 more
TL;DR: Analysis of genome-wide expression data in 51 human tissues from the Novartis Research Foundation showed that median GWAS significance levels for SNPs in genes expressed in the lung differed most significantly from genes not expressed inThe lung when compared to 50 other tissues, supporting the biological plausibility of the overall GWAS findings and the multigenic etiology of childhood asthma.
Journal ArticleDOI
Prospective study of breast-feeding in relation to wheeze, atopy, and bronchial hyperresponsiveness in the Avon Longitudinal Study of Parents and Children (ALSPAC)
Leslie Elliott,John Henderson,John Henderson,Kate Northstone,Grace Y. Chiu,David B. Dunson,Stephanie J. London +6 more
TL;DR: No consistent evidence for either a deleterious effect or a protective effect of breast-feeding on later risk of allergic disease in a large prospective birth cohort of children with objective outcome measures and extensive data on potential confounders and effect modifiers is found.
Journal ArticleDOI
Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans
Hao Wu,Isabelle Romieu,Min Shi,Dana B. Hancock,Huiling Li,J. J. L. Sienra-Monge,Grace Y. Chiu,Hong Xu,Blanca Estela Del Río-Navarro,Stephanie J. London +9 more
TL;DR: It is suggested that SNPs in several candidate genes, including TGFB 1, IL1RL1, IL18R1, and DPP10, might contribute to childhood asthma susceptibility in a Mexican population.
Journal ArticleDOI
Genetic polymorphisms in arginase I and II and childhood asthma and atopy.
Huiling Li,Isabelle Romieu,J. J. L. Sienra-Monge,Matiana Ramirez-Aguilar,Blanca Estela Del Río-Navarro,Emily O. Kistner,Håkon K. Gjessing,Irma del Carmen Lara-Sanchez,Grace Y. Chiu,Stephanie J. London +9 more
TL;DR: Variation in arginase genes may contribute to asthma and atopy in children and is associated with a statistically significant increased relative risk of asthma.