M
Mezbah U. Faruque
Researcher at Howard University
Publications - 22
Citations - 2254
Mezbah U. Faruque is an academic researcher from Howard University. The author has contributed to research in topics: Genome-wide association study & Asthma. The author has an hindex of 14, co-authored 22 publications receiving 1995 citations. Previous affiliations of Mezbah U. Faruque include University of Washington.
Papers
More filters
Journal ArticleDOI
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations
Dara G. Torgerson,Dara G. Torgerson,Elizabeth J. Ampleford,Grace Y. Chiu,W. James Gauderman,Christopher R. Gignoux,Penelope E. Graves,Blanca E. Himes,Albert M. Levin,Rasika A. Mathias,Dana B. Hancock,Dana B. Hancock,Dana B. Hancock,James W. Baurley,Celeste Eng,Debra A. Stern,Juan C. Celedón,Nicholas Rafaels,Daniel Capurso,David V. Conti,Lindsey A. Roth,Manuel Soto-Quiros,Alkis Togias,Xingnan Li,Rachel A. Myers,Isabelle Romieu,Isabelle Romieu,David Van Den Berg,Donglei Hu,Nadia N. Hansel,Ryan D. Hernandez,Elliott Israel,Muhammad T. Salam,Joshua Galanter,Pedro C. Avila,Lydiana Avila,Jose R. Rodriquez-Santana,R. Chapela,William Rodríguez-Cintrón,Gregory B. Diette,N. Franklin Adkinson,Rebekah A. Abel,K. Ross,Min Shi,Mezbah U. Faruque,Georgia M. Dunston,Harold Watson,Vito J. Mantese,Serpil C. Ezurum,Liming Liang,Ingo Ruczinski,Jean G. Ford,Scott Huntsman,Kian Fan Chung,Hita Vora,Xia Li,William J. Calhoun,Mario Castro,Juan José Luis Sienra-Monge,Blanca Estela Del Río-Navarro,Klaus A. Deichmann,Andrea Heinzmann,Sally E. Wenzel,William W. Busse,William W. Busse,James E. Gern,Robert F. Lemanske,Terri H. Beaty,Eugene R. Bleecker,Benjamin A. Raby,Deborah A. Meyers,Stephanie J. London,Frank D. Gilliland,Esteban G. Burchard,Fernando D. Martinez,Scott T. Weiss,L. Keoki Williams,Kathleen C. Barnes,Carole Ober,Dan L. Nicolae +79 more
TL;DR: The results suggest that some asthma susceptibility loci are robust to differences in ancestry when sufficiently large samples sizes are investigated, and that ancestry-specific associations also contribute to the complex genetic architecture of asthma.
Journal ArticleDOI
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
Agnar Helgason,Snæbjörn Pálsson,Snæbjörn Pálsson,Gudmar Thorleifsson,Struan F.A. Grant,Struan F.A. Grant,Valur Emilsson,Steinunn Gunnarsdottir,Adebowale Adeyemo,Yuanxiu Chen,Guanjie Chen,Inga Reynisdottir,Rafn Benediktsson,Anke Hinney,Torben Hansen,Gitte Andersen,Knut Borch-Johnsen,Knut Borch-Johnsen,Torben Jørgensen,Helmut Schäfer,Mezbah U. Faruque,Ayo Doumatey,Jie Zhou,Robert L. Wilensky,Muredach P. Reilly,Daniel J. Rader,Yu Z. Bagger,Claus Christiansen,Gunnar Sigurdsson,Johannes Hebebrand,Oluf Pedersen,Oluf Pedersen,Unnur Thorsteinsdottir,Jeffrey R. Gulcher,Augustine Kong,Charles N. Rotimi,Kari Stefansson +36 more
TL;DR: Another variant of the TCF7L2 type 2 diabetes risk variant, HapBT2D, is identified that shows evidence of positive selection in East Asian, European and West African populations, indicating that the selective advantage of HapA may have been mediated through effects on energy metabolism.
Journal ArticleDOI
Assembly of a pan-genome from deep sequencing of 910 humans of African descent
Rachel M. Sherman,Juliet Forman,Juliet Forman,Valentin Antonescu,Daniela Puiu,Michelle Daya,Nicholas Rafaels,Meher Preethi Boorgula,Sameer Chavan,Candelaria Vergara,Victor E. Ortega,Albert M. Levin,Celeste Eng,Maria Yazdanbakhsh,James G. Wilson,Javier Marrugo,Leslie A. Lange,L. Keoki Williams,Harold Watson,Lorraine B. Ware,Christopher O. Olopade,Olufunmilayo I. Olopade,Ricardo Riccio Oliveira,Carole Ober,Dan L. Nicolae,Deborah A. Meyers,Alvaro Mayorga,Jennifer Knight-Madden,Tina V. Hartert,Nadia N. Hansel,Marilyn G. Foreman,Jean G. Ford,Mezbah U. Faruque,Georgia M. Dunston,Luis Caraballo,Esteban G. Burchard,Eugene R. Bleecker,Maria Ilma Araujo,Edwin Francisco Herrera-Paz,Monica Campbell,Cassandra Foster,Margaret A. Taub,Terri H. Beaty,Ingo Ruczinski,Rasika A. Mathias,Kathleen C. Barnes,Steven L. Salzberg +46 more
TL;DR: A deeply sequenced dataset of 910 individuals, all of African descent, is used to construct a set of DNA sequences that is present in these individuals but missing from the reference human genome, demonstrating that the African pan-genome contains ~10% more DNA than the current human reference genome.
Journal ArticleDOI
A genome-wide association study on African-ancestry populations for asthma.
Rasika A. Mathias,Audrey V. Grant,Nicholas Rafaels,T. Hand,Li Gao,Candelaria Vergara,Yuhjung J. Tsai,Mao Yang,Monica Campbell,Cassandra Foster,Peisong Gao,Alkis Togias,Nadia N. Hansel,Gregory B. Diette,N. Franklin Adkinson,Mark C. Liu,Mezbah U. Faruque,Georgia M. Dunston,Harold Watson,Michael B. Bracken,Josephine Hoh,Pissamai Maul,Trevor Maul,Anne E. Jedlicka,Tanda Murray,Jacqueline B. Hetmanski,Roxann Ashworth,Chrissie M. Ongaco,Kurt N. Hetrick,Kimberly F. Doheny,Elizabeth W. Pugh,Charles N. Rotimi,Jean G. Ford,Celeste Eng,Esteban G. Burchard,Patrick M. A. Sleiman,Hakon Hakonarson,Erick Forno,Benjamin A. Raby,Scott T. Weiss,Alan F. Scott,Michael Kabesch,Liming Liang,Gonçalo R. Abecasis,Miriam F. Moffatt,William O.C.M. Cookson,Ingo Ruczinski,Terri H. Beaty,Kathleen C. Barnes +48 more
TL;DR: This study illustrates the complexity of identifying true associations for a complex and heterogeneous disease, such as asthma, in admixed populations, especially populations of African descent.
Journal ArticleDOI
A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome
Rasika A. Mathias,Margaret A. Taub,Christopher R. Gignoux,Wenqing Fu,Shaila Musharoff,Timothy D. O’Connor,Candelaria Vergara,Dara G. Torgerson,Maria Pino-Yanes,Suyash Shringarpure,Lili Huang,Nicholas Rafaels,Meher Preethi Boorgula,Henry Richard Johnston,Victor E. Ortega,Albert M. Levin,Wei Song,Raul Torres,Badri Padhukasahasram,Celeste Eng,Delmy Aracely Mejia-Mejia,Trevor S. Ferguson,Zhaohui S. Qin,Alan F. Scott,Maria Yazdanbakhsh,James G. Wilson,Javier Marrugo,Leslie A. Lange,Rajesh Kumar,Rajesh Kumar,Pedro C. Avila,L. Keoki Williams,Harold Watson,Lorraine B. Ware,Christopher O. Olopade,Olufunmilayo I. Olopade,Ricardo Riccio Oliveira,Carole Ober,Dan L. Nicolae,Deborah A. Meyers,Alvaro Mayorga,Jennifer Knight-Madden,Tina V. Hartert,Nadia N. Hansel,Marilyn G. Foreman,Jean G. Ford,Jean G. Ford,Mezbah U. Faruque,Georgia M. Dunston,Luis Caraballo,Esteban G. Burchard,Eugene R. Bleecker,Maria Ilma Araujo,Edwin Francisco Herrera-Paz,Kimberly Gietzen,Wendy E. Grus,Michael J. Bamshad,Carlos Bustamante,Eimear E. Kenny,Eimear E. Kenny,Ryan D. Hernandez,Ryan D. Hernandez,Terri H. Beaty,Ingo Ruczinski,Joshua M. Akey,Kathleen C. Barnes +65 more
TL;DR: Genetic variation from deeply sequenced genomes of 642 individuals from North and South American, Caribbean and West African populations is presented, substantially increasing the lexicon of human genomic variation and suggesting much variation remains to be discovered in African-admixed populations in the Americas.