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Brian P. Chadwick
Researcher at Florida State University
Publications - 65
Citations - 4453
Brian P. Chadwick is an academic researcher from Florida State University. The author has contributed to research in topics: Heterochromatin & Gene. The author has an hindex of 32, co-authored 65 publications receiving 4185 citations. Previous affiliations of Brian P. Chadwick include Duke University & Harvard University.
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Journal ArticleDOI
Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia.
Susan A. Slaugenhaupt,Anat Blumenfeld,Sandra Gill,Maire Leyne,James Mull,Math P. Cuajungco,Christopher B. Liebert,Brian P. Chadwick,Maria Idelson,Luba Reznik,Christiane M. Robbins,Izabela Makalowska,Michael J. Brownstein,Daniel Krappmann,Claus Scheidereit,Channa Maayan,Felicia B. Axelrod,James F. Gusella +17 more
TL;DR: It is indicated that almost all cases of FD are caused by an unusual splice defect that displays tissue-specific expression; and they also provide the basis for rapid carrier screening in the Ashkenazi Jewish population.
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A unified phylogeny-based nomenclature for histone variants
Paul B. Talbert,Kami Ahmad,Geneviève Almouzni,Juan Ausió,Frédéric Berger,Prem L. Bhalla,William M. Bonner,W. Zacheus Cande,Brian P. Chadwick,Simon W. L. Chan,George A. M. Cross,Liwang Cui,Stefan Dimitrov,Detlef Doenecke,José M. Eirín-López,Martin A. Gorovsky,Sandra B. Hake,Barbara A. Hamkalo,Sarah Holec,Steven E. Jacobsen,Kinga Kamieniarz,Saadi Khochbin,Andreas G. Ladurner,David Landsman,John A Latham,Benjamin Loppin,Harmit S. Malik,William F. Marzluff,John R. Pehrson,Jan Postberg,Robert Schneider,Mohan Singh,M. Mitchel Smith,Eric M. Thompson,Maria-Elena Torres-Padilla,David J. Tremethick,Bryan M. Turner,Jakob H. Waterborg,Heike Wollmann,Ramesh Yelagandula,Bing Zhu,Steven Henikoff +41 more
TL;DR: A unified nomenclature for variants of all five classes of histones is proposed that uses consistent but flexible naming conventions to produce names that are informative and readily searchable and incorporates phylogenetic relationships, which are strong predictors of structure and function.
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Ring1b-mediated H2A Ubiquitination Associates with Inactive X Chromosomes and Is Involved in Initiation of X Inactivation
TL;DR: Evidence is provided that supports H2A ubiquitination as a novel epigenetic marker for the inactive X chromosome (Xi) and links H2a ubiquitinations to initiation of X inactivation and the association of Ring1b and ubH2A with Xi is mitotically stable in non-differentiated TS cells.
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Deletion of DXZ4 on the human inactive X chromosome alters higher-order genome architecture.
Emily M. Darrow,Miriam H. Huntley,Olga Dudchenko,Elena Stamenova,Neva C. Durand,Zhuo Sun,Su Chen Huang,Adrian L. Sanborn,Ido Machol,Muhammad S. Shamim,Andrew P. Seberg,Eric S. Lander,Brian P. Chadwick,Erez Lieberman Aiden +13 more
TL;DR: 3D mapping, microscopy, and genome editing are combined to study the structure of the inactive X chromosome, focusing on the role of DXZ4, and it is found that superloops and superdomains are conserved across humans, macaque, and mouse.
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Identification of amplified restriction fragment polymorphism (AFLP) markers tightly linked to the tomato Cf-9 gene for resistance to Cladosporium fulvum
Colwyn M. Thomas,Pieter Vos,Marc Zabeau,David A. Jones,Karen A. Norcott,Brian P. Chadwick,Jonathan D. G. Jones +6 more
TL;DR: AFLP analysis provides a rapid and efficient technique for detecting large numbers of DNA markers and should expedite plant gene isolation by positional cloning and the construction of high-density molecular linkage maps of plant genomes.