C
Cameron S. Osborne
Researcher at King's College London
Publications - 51
Citations - 9414
Cameron S. Osborne is an academic researcher from King's College London. The author has contributed to research in topics: Gene & Enhancer. The author has an hindex of 26, co-authored 49 publications receiving 8589 citations. Previous affiliations of Cameron S. Osborne include University of Adelaide & Babraham Institute.
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Journal ArticleDOI
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.
Salima Hacein-Bey-Abina,C von Kalle,C von Kalle,Manfred Schmidt,Matthew P. McCormack,NM Wulffraat,Philippe Leboulch,Annick Lim,Cameron S. Osborne,R. Pawliuk,Estelle Morillon,R. Sorensen,A. Forster,Peter Fraser,Jeffrey I. Cohen,G de Saint Basile,Ian E. Alexander,Uwe Wintergerst,Thierry Frebourg,Alain Aurias,Dominique Stoppa-Lyonnet,Serge Romana,I. Radford-Weiss,Fabian Gross,Françoise Valensi,Eric Delabesse,Elizabeth Macintyre,F. Sigaux,Jean Soulier,L. E. Leiva,Manuela Wissler,Claudia Prinz,Terence H. Rabbitts,F. Le Deist,Alain Fischer,Marina Cavazzana-Calvo +35 more
TL;DR: Retrovirus vector insertion can trigger deregulated premalignant cell proliferation with unexpected frequency, most likely driven by retrovirus enhancer activity on the LMO2 gene promoter.
Journal ArticleDOI
Active genes dynamically colocalize to shared sites of ongoing transcription.
Cameron S. Osborne,Lyubomira Chakalova,Karen E. Brown,David R. F. Carter,David R. F. Carter,Alice Horton,Emmanuel Debrand,Beatriz Goyenechea,Jennifer A. Mitchell,Susana Lopes,Susana Lopes,Wolf Reik,Peter Fraser +12 more
TL;DR: It is shown that, during transcription in vivo, distal genes colocalize to the same transcription factory at high frequencies.
Journal ArticleDOI
Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C
Borbala Mifsud,Filipe Tavares-Cadete,Alice N Young,Robert Sugar,Stefan Schoenfelder,Lauren Ferreira,Steven W. Wingett,Simon Andrews,William Grey,Philip Ewels,Bram Herman,Scott Happe,Andy Higgs,Emily M LeProust,George A. Follows,Peter Fraser,Nicholas M. Luscombe,Cameron S. Osborne +17 more
TL;DR: In this article, the authors use Capture Hi-C (CHi-C) to examine the long-range interactions of almost 22,000 promoters in 2 human blood cell types and identify over 1.6 million shared and cell type-restricted interactions spanning hundreds of kilobases between promoters and distal loci.
Journal ArticleDOI
Long-range chromatin regulatory interactions in vivo
TL;DR: The development of a widely applicable in situ technique to tag and recover chromatin in the immediate vicinity of an actively transcribed gene and provide the first direct evidence of long-range enhancer communication is reported.
Journal ArticleDOI
The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements
Stefan Schoenfelder,Mayra Furlan-Magaril,Borbala Mifsud,Filipe Tavares-Cadete,Filipe Tavares-Cadete,Robert Sugar,Biola M. Javierre,Takashi Nagano,Yulia Katsman,Moorthy Sakthidevi,Steven W. Wingett,Emilia Dimitrova,Andrew Dimond,Lucas Brandon Edelman,Sarah Elderkin,Kristina Tabbada,Elodie Darbo,Elodie Darbo,Simon Andrews,Bram Herman,Andy Higgs,Emily M LeProust,Cameron S. Osborne,Jennifer A. Mitchell,Nicholas M. Luscombe,Nicholas M. Luscombe,Peter Fraser +26 more
TL;DR: The results provide the first genome-wide catalog linking gene promoters to their long-range interacting elements and highlight the complex spatial regulatory circuitry controlling mammalian gene expression.