Cathleen M. Brdlik

TL;DR: These studies identified regions of the nematode and fly genomes that show highly occupied targets (or HOT) regions where DNA was bound by more than 15 of the transcription factors analyzed and the expression of related genes were characterized, providing insights into the organization, structure, and function of the two genomes.

TL;DR: Examination of the binding targets of three related HOX factors--LIN-39, MAB-5, and EGL-5--indicates that these factors regulate genes involved in cellular migration, neuronal function, and vulval differentiation, consistent with their known roles in these developmental processes.

TL;DR: The results suggest that gene-regulatory properties previously observed for individual factors are general principles of metazoan regulation that are remarkably well-preserved despite extensive functional divergence of individual network connections.

TL;DR: In this article, the genome-wide binding locations of 165 human, 93 worm and 52 fly transcription regulatory factors were mapped for a total of 1,019 data sets from diverse cell types, developmental stages, or conditions in the three species, of which 498 (48.9%) are presented here for the first time.

TL;DR: ChIP-Seq combines ChIP with massively parallel high-throughput sequencing and has demonstrated vast improvement over ChIP-chip with respect to time and cost, signal-to-noise ratio, and resolution.