Thea A. Egelhofer

TL;DR: These studies identified regions of the nematode and fly genomes that show highly occupied targets (or HOT) regions where DNA was bound by more than 15 of the transcription factors analyzed and the expression of related genes were characterized, providing insights into the organization, structure, and function of the two genomes.

TL;DR: The specificity and utility of histone-modification antibodies raised against 57 different histone modifications in Drosophila melanogaster, Caenorhabditis elegans and human cells are tested.

TL;DR: Comparison of combinatorial patterns of histone modifications, nuclear lamina-associated domains, organization of large-scale topological domains, chromatin environment at promoters and enhancers, nucleosome positioning, and DNA replication patterns reveals many conserved features of chromatin organization among the three organisms.

TL;DR: The genome-wide distributions of 19 histone modifications, one histone variant, and eight chromatin-associated proteins in Caenorhabditis elegans embryos and L3 larvae are defined, allowing for in-depth analysis of the organization and deployment of the C. elegans genome during development.

TL;DR: It is proposed that MES-4 transmits the memory of gene expression in the parental germ line to offspring and that this memory role is critical for the PGCs to execute a proper germline program.