C
Charles E. Rupprecht
Researcher at Wistar Institute
Publications - 484
Citations - 29552
Charles E. Rupprecht is an academic researcher from Wistar Institute. The author has contributed to research in topics: Rabies & Rabies virus. The author has an hindex of 86, co-authored 475 publications receiving 27058 citations. Previous affiliations of Charles E. Rupprecht include United States Department of Health and Human Services & Global Alliance for Rabies Control.
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Journal ArticleDOI
Development of a cocktail of recombinant-expressed human rabies virus-neutralizing monoclonal antibodies for postexposure prophylaxis of rabies.
Mikhail Prosniak,Milosz Faber,Cathleen A. Hanlon,Charles E. Rupprecht,D. Craig Hooper,Bernhard Dietzschold +5 more
TL;DR: In the mouse models, the postexposure prophylaxis (PEP) efficacy obtained with the rhuMAb cocktail was comparable to that obtained with HRIG, a finding strongly suggesting that rhuMAbs should be given serious consideration for use in future PEP of humans.
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A suspected canine distemper epidemic as the cause of a catastrophic decline in Santa Catalina Island foxes (Urocyon littoralis catalinae).
Steven F. Timm,Linda Munson,Brian A. Summers,Karen A. Terio,Edward J. Dubovi,Charles E. Rupprecht,Sanjay Kapil,David K. Garcelon +7 more
TL;DR: Evidence of exposure to CDV in east-end foxes in 1999–2000 compared to 1998, and documentation of raccoon introductions to the island, implicates canine distemper as the cause of the population decline.
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A review of the economics of the prevention and control of rabies. Part 2: Rabies in dogs, livestock and wildlife.
TL;DR: Despite a definite decline in the number of rabid foxes, it has been difficult to obtain the promised benefits of using oral vaccines in Europe to control fox rabies, and only a few papers contain a multi-year framework, complete with discounting of future costs and benefits.
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Novel Rabies Virus-Neutralizing Epitope Recognized by Human Monoclonal Antibody: Fine Mapping and Escape Mutant Analysis
Wilfred E. Marissen,R. Arjen Kramer,Amy B. Rice,William C. Weldon,Michael Niezgoda,Milosz Faber,Jerry W. Slootstra,Rob H. Meloen,Marieke Clijsters-van der Horst,Therese Visser,Mandy Jongeneelen,Sandra Thijsse,Mark Throsby,John de Kruif,Charles E. Rupprecht,Bernhard Dietzschold,Jaap Goudsmit,Alexander Berthold Hendrik Bakker +17 more
TL;DR: The competition between CR57 and CRJB, the in vitro escape profile, and the apparent overlap between the recognized epitopes argues against including bothCR57 andCRJB in a MAb cocktail aimed at replacing classical immunoglobulin preparations.
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Efficacy of an oral vaccinia-rabies glycoprotein recombinant vaccine in controlling epidemic raccoon rabies in New Jersey
Douglas E. Roscoe,Warren C. Holste,Faye E. Sorhage,Colin Campbell,Michael Niezgoda,Raymond Buchannan,Daniel Diehl,Hong Shin Niu,Charles E. Rupprecht +8 more
TL;DR: The breach of the vaccination area resulted in a resumption of the high rate of epidemic movement and a significant nine-fold increase in rabies prevalence, and insufficient funding and a decision to discontinue the program in 1994 may have contributed to the eventual breached of the barrier.