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Charles E. Rupprecht

Researcher at Wistar Institute

Publications -  484
Citations -  29552

Charles E. Rupprecht is an academic researcher from Wistar Institute. The author has contributed to research in topics: Rabies & Rabies virus. The author has an hindex of 86, co-authored 475 publications receiving 27058 citations. Previous affiliations of Charles E. Rupprecht include United States Department of Health and Human Services & Global Alliance for Rabies Control.

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Host Phylogeny Constrains Cross-Species Emergence and Establishment of Rabies Virus in Bats

TL;DR: Using a data set of hundreds of rabies viruses sampled from 23 North American bat species, a general framework is presented to quantify per capita rates of cross-species transmission and reconstruct historical patterns of viral establishment in new host species using molecular sequence data, which demonstrate diminishing frequencies of both cross- species transmission and host shifts with increasing phylogenetic distance between bat species.
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Human rabies: a disease of complex neuropathogenetic mechanisms and diagnostic challenges

TL;DR: Rabies is inevitably fatal and presents a horrifying clinical picture, particularly the paralytic form, which closely resembles Guillain-Barre syndrome, or when a patient is comatose and cardinal signs may be lacking.
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Function and glycosylation of plant-derived antiviral monoclonal antibody

TL;DR: The plant-derived human anti-rabies mAb (mAbP) was as efficient as HRIG for post-exposure prophylaxis against rabies virus in hamsters, indicating that differences in N-glycosylation do not affect the efficacy of the antibody in this model.