C
Charles E. Rupprecht
Researcher at Wistar Institute
Publications - 484
Citations - 29552
Charles E. Rupprecht is an academic researcher from Wistar Institute. The author has contributed to research in topics: Rabies & Rabies virus. The author has an hindex of 86, co-authored 475 publications receiving 27058 citations. Previous affiliations of Charles E. Rupprecht include United States Department of Health and Human Services & Global Alliance for Rabies Control.
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Journal ArticleDOI
Host Phylogeny Constrains Cross-Species Emergence and Establishment of Rabies Virus in Bats
Daniel G. Streicker,Daniel G. Streicker,Amy S. Turmelle,Amy S. Turmelle,Maarten J. Vonhof,Ivan V. Kuzmin,Gary F. McCracken,Charles E. Rupprecht +7 more
TL;DR: Using a data set of hundreds of rabies viruses sampled from 23 North American bat species, a general framework is presented to quantify per capita rates of cross-species transmission and reconstruct historical patterns of viral establishment in new host species using molecular sequence data, which demonstrate diminishing frequencies of both cross- species transmission and host shifts with increasing phylogenetic distance between bat species.
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Human rabies: a disease of complex neuropathogenetic mechanisms and diagnostic challenges
TL;DR: Rabies is inevitably fatal and presents a horrifying clinical picture, particularly the paralytic form, which closely resembles Guillain-Barre syndrome, or when a patient is comatose and cardinal signs may be lacking.
Journal ArticleDOI
Correction: Estimating the global burden of endemic canine rabies.
Katie Hampson,Laurent Coudeville,Tiziana Lembo,Maganga Sambo,Alexia Kieffer,Michaël Attlan,Jacques Barrat,Jesse D. Blanton,Deborah J. Briggs,Sarah Cleaveland,Peter Costa,Conrad M. Freuling,Elly Hiby,Lea Knopf,Fernando Leanes,François-Xavier Meslin,A. E. Metlin,Mary Elizabeth Miranda,Thomas Müller,Louis Hendrik Nel,Sergio Recuenco,Charles E. Rupprecht,Carolin L. Schumacher,Louise H. Taylor,Marco Antonio,Natal Vigilato,Jakob Zinsstag,Jonathan Dushoff,Global Alliance for Rabies Control Partners for Rabies Prevention +28 more
TL;DR: There are a number of errors in Table 3.
Journal ArticleDOI
Bats are a major natural reservoir for hepaciviruses and pegiviruses
Phenix-Lan Quan,Cadhla Firth,Juliette M. Conte,Simon H. Williams,Carlos Zambrana-Torrelio,Simon J. Anthony,Simon J. Anthony,James A. Ellison,Amy T. Gilbert,Ivan V. Kuzmin,Michael Niezgoda,Modupe O. V. Osinubi,Sergio Recuenco,Wanda Markotter,Robert F. Breiman,Lem’s N. Kalemba,Jean Malekani,Kim A. Lindblade,Melinda K. Rostal,Rafael Ojeda-Flores,Gerardo Suzán,Lora Davis,Dianna M. Blau,A. B. Ogunkoya,Danilo A. Alvarez Castillo,David Moran,Sali Ngam,Dudu Akaibe,Bernard Agwanda,Thomas Briese,Jonathan H. Epstein,Peter Daszak,Charles E. Rupprecht,Edward C. Holmes,W. Ian Lipkin +34 more
TL;DR: The prevalence, unprecedented viral biodiversity, phylogenetic divergence, and worldwide distribution of the bat-derived viruses suggest that bats are a major and ancient natural reservoir for both hepaciviruses and pegivirus and provide insights into the evolutionary history of hepatitis C virus and the human GB viruses.
Journal ArticleDOI
Function and glycosylation of plant-derived antiviral monoclonal antibody
Kisung Ko,Yoram Tekoah,Pauline M. Rudd,David Harvey,Raymond A. Dwek,Sergei Spitsin,Cathleen A. Hanlon,Charles E. Rupprecht,Bernhard Dietzschold,Maxim Golovkin,Hilary Koprowski +10 more
TL;DR: The plant-derived human anti-rabies mAb (mAbP) was as efficient as HRIG for post-exposure prophylaxis against rabies virus in hamsters, indicating that differences in N-glycosylation do not affect the efficacy of the antibody in this model.