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Charles E. Rupprecht
Researcher at Wistar Institute
Publications - 484
Citations - 29552
Charles E. Rupprecht is an academic researcher from Wistar Institute. The author has contributed to research in topics: Rabies & Rabies virus. The author has an hindex of 86, co-authored 475 publications receiving 27058 citations. Previous affiliations of Charles E. Rupprecht include United States Department of Health and Human Services & Global Alliance for Rabies Control.
Papers
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Journal ArticleDOI
Identification and characterization of a human monoclonal antibody that potently neutralizes a broad panel of rabies virus isolates.
Susan Sloan,Cathleen A. Hanlon,William C. Weldon,Michael Niezgoda,Jesse D. Blanton,Josh Self,Kirk J. Rowley,Robert Mandell,Gregory J. Babcock,William D. Thomas,Charles E. Rupprecht,Donna M. Ambrosino +11 more
TL;DR: HuMAb 17C7 was the most promising antibody identified because it neutralized all rabies virus isolates tested and protected hamsters from a lethal dose of rabiesirus in a well-established in vivo model of post-exposure prophylaxis.
Book ChapterDOI
Emergence of lyssaviruses in the Old World: the case of Africa.
TL;DR: Both Duvenhage and Lagos bat viruses are adapted to bats, but their epidemiology, together with Mokola virus, is poorly understood, which is a major cause for concern among these emerging viral agents.
Journal Article
Rabies and borna disease. A comparative pathogenetic study of two neurovirulent agents.
G. Gosztonyi,Bernhard Dietzschold,Moujahed Kao,Charles E. Rupprecht,Hanns Ludwig,Hilary Koprowski +5 more
TL;DR: A major difference exists between the two agents insofar as rabies virus is morphologically well characterized, whereas BDV has never been visualized in tissue sections, and the synaptic transfer of both viruses likely ensures in the form of bare nucleocapsids (ribonucleoprotein-transcriptase complexes).
Journal ArticleDOI
Bartonella spp. in Bats, Guatemala.
Ying Bai,Michael Kosoy,Sergio Recuenco,Danilo Alvarez,David Moran,Amy S. Turmelle,James A. Ellison,Daniel L. Garcia,Alejandra Estevez,Kim A. Lindblade,Charles E. Rupprecht +10 more
TL;DR: This work estimated Bartonella spp.
Journal ArticleDOI
A Human Monoclonal Antibody Cocktail as a Novel Component of Rabies Postexposure Prophylaxis
John de Kruif,Alexander Berthold Hendrik Bakker,Wilfred E. Marissen,R. Arjen Kramer,Mark Throsby,Charles E. Rupprecht,Jaap Goudsmit +6 more
TL;DR: The criteria used to guide development of a cocktail of human monoclonal antibodies as a replacement for RIG are set out and the general requirements for development of safe and efficacious monOClonal antibody alternatives to currently used polyclonal serum products are discussed.