C
Charles E. Rupprecht
Researcher at Wistar Institute
Publications - 484
Citations - 29552
Charles E. Rupprecht is an academic researcher from Wistar Institute. The author has contributed to research in topics: Rabies & Rabies virus. The author has an hindex of 86, co-authored 475 publications receiving 27058 citations. Previous affiliations of Charles E. Rupprecht include United States Department of Health and Human Services & Global Alliance for Rabies Control.
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Journal ArticleDOI
Oral immunization of raccoons and skunks with a canine adenovirus recombinant rabies vaccine.
Heather Henderson,Felix R. Jackson,Kayla Bean,Brian Panasuk,Michael Niezgoda,Dennis Slate,Jianwei Li,Bernard Dietzschold,Jeff Mattis,Jeff Mattis,Jeff Mattis,Charles E. Rupprecht +11 more
TL;DR: The results of this preliminary study suggest that CAV2-RVG stimulates protective immunity against rabies in raccoons and skunks.
Journal ArticleDOI
Oral Efficacy of an Attenuated Rabies Virus Vaccine in Skunks and Raccoons
TL;DR: Evaluated SAG-2 rabies virus vaccine for safety, immunogenicity, and efficacy by the oral route in skunks and raccoons found to satisfy both safety and efficacy concerns for oral rabies immunization of major North American rabies reservoirs.
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Report on the international workshop on alternative methods for human and veterinary rabies vaccine testing: state of the science and planning the way forward.
William S. Stokes,Richard McFarland,Jodie Kulpa-Eddy,Donna M. Gatewood,Robin Levis,Marlies Halder,Gayle Pulle,Hajime Kojima,Warren Casey,Alexander Gaydamaka,Timothy J. Miller,Karen Brown,Charles E. Lewis,Jean-Michel Chapsal,Lukas Bruckner,Sunil Gairola,Elisabeth Kamphuis,Charles E. Rupprecht,Peter S. Wunderli,Lorraine M. McElhinney,Fabrizio De Mattia,Koichiro Gamoh,Richard Hill,David L. Reed,Vivian W. Doelling,Nelson W Johnson,David J. Allen,Lori Rinckel,Brett Jones +28 more
TL;DR: A workshop to review the availability and validation status of alternative methods that might reduce, refine, or replace the use of animals for rabies vaccine potency testing, and to identify research and development efforts to further advance alternative methods, agreed that general anesthesia should be used for intracerebral virus injections.
Journal Article
Viral excretion in domestic ferrets (mustela putorius furo) inoculated with a raccoon rabies isolate
TL;DR: Rabies should be considered in the differential diagnosis for ferrets that have acute onset of paralysis or behavioral changes and a condition that rapidly deteriorates despite intense medical intervention.
Journal ArticleDOI
Glycoprotein gene relocation in rabies virus
Xianfu Wu,Charles E. Rupprecht +1 more
TL;DR: An efficient system for the Evelyn-Rokitnicki-Abelseth rabies virus with the glycoprotein gene switched with the matrix protein gene, creating a reshuffled virus ERAgm (gene order N-P-G-M-L), which provides a potential novel method for rabies vaccine development.