C
Christian Frantz
Researcher at University of California, San Francisco
Publications - 4
Citations - 3648
Christian Frantz is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Sodium–hydrogen antiporter & Actin. The author has an hindex of 4, co-authored 4 publications receiving 2866 citations.
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Journal ArticleDOI
The extracellular matrix at a glance
TL;DR: The extracellular matrix is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue development.
Journal ArticleDOI
Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding.
Christian Frantz,Gabriela Barreiro,Laura Dominguez,Xiaoming Chen,Robert J. Eddy,John S. Condeelis,Mark J. S. Kelly,Matthew P. Jacobson,Diane L. Barber +8 more
TL;DR: A molecular mechanism whereby cofilin acts as a pH sensor to mediate a pH-dependent actin filament dynamics is suggested, which suggests that it has a more complex behavior in cells.
Journal ArticleDOI
A physical sciences network characterization of non-tumorigenic and metastatic cells
David B. Agus,Jenolyn F. Alexander,Wadih Arap,S.P. Ashili,Joseph E. Aslan,Robert H. Austin,Vadim Backman,Kelly Bethel,Richard Bonneau,Wei Chiang Chen,Chira Chen-Tanyolac,Nathan C. Choi,Steven A. Curley,Matthew R. Dallas,Dhwanil Damania,Paul Davies,Paolo Decuzzi,Laura E. Dickinson,Luis Estévez-Salmerón,Veronica Estrella,Mauro Ferrari,Claudia Fischbach,Jasmine Foo,Stephanie I. Fraley,Christian Frantz,Alexander Fuhrmann,Philippe Gascard,Robert A. Gatenby,Yue Geng,Sharon Gerecht,Robert J. Gillies,Biana Godin,William M. Grady,William M. Grady,Alex Greenfield,Courtney Hemphill,Barbara L. Hempstead,Abigail Hielscher,W. Daniel Hillis,Eric C. Holland,Arig Ibrahim-Hashim,Tyler Jacks,Roger H. Johnson,Ahyoung Joo,Jonathan E. Katz,Laimonas Kelbauskas,Carl Kesselman,Michael R. King,Konstantinos Konstantopoulos,Casey M. Kraning-Rush,Peter Kuhn,Kevin S. Kung,Brian J. Kwee,Johnathon N. Lakins,Guillaume Lambert,David Liao,Jonathan D. Licht,Jan Liphardt,Jan Liphardt,Liyu Liu,Mark C. Lloyd,Anna Lyubimova,Parag Mallick,Parag Mallick,John F. Marko,Owen J. T. McCarty,Deirdre R. Meldrum,Franziska Michor,Shannon M. Mumenthaler,Vivek Nandakumar,Thomas V. O'Halloran,Steve Oh,Renata Pasqualini,Matthew J. Paszek,Kevin G. Philips,Christopher S. Poultney,Kuldeepsinh Rana,Cynthia A. Reinhart-King,Robert Ros,Gregg L. Semenza,Patti Senechal,Michael L. Shuler,Srimeenakshi Srinivasan,Jack R. Staunton,Yolanda Stypula,Hariharan Subramanian,Thea D. Tlsty,Garth W. Tormoen,Yiider Tseng,Yiider Tseng,Alexander van Oudenaarden,Scott S. Verbridge,Scott S. Verbridge,Jenny C. Wan,Valerie M. Weaver,Jonathan Widom,Christine Will,Denis Wirtz,Jonathan W. Wojtkowiak,Pei Hsun Wu +99 more
TL;DR: Comparisons of the non-tumorigenic MCF-10A and metastatic MDA-MB-231 breast epithelial cell lines, commonly used as models of cancer metastasis, reveal dramatic differences in their mechanics, migration, adhesion, oxygen response, and proteomic profiles.
Journal ArticleDOI
Positive feedback between Cdc42 activity and H+ efflux by the Na-H exchanger NHE1 for polarity of migrating cells
TL;DR: Data indicate that GEF binding to phosphotidylinositol 4,5–bisphosphate is pH dependent, suggesting a mechanism for how H+ efflux by NHE1 promotes Cdc42 activity to generate a positive feedback signal necessary for polarity in migrating cells.