A
Arig Ibrahim-Hashim
Researcher at University of South Florida
Publications - 28
Citations - 2670
Arig Ibrahim-Hashim is an academic researcher from University of South Florida. The author has contributed to research in topics: Tumor microenvironment & Cancer. The author has an hindex of 16, co-authored 28 publications receiving 1995 citations. Previous affiliations of Arig Ibrahim-Hashim include Moffitt Cancer Center & University of Alabama at Birmingham.
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Journal ArticleDOI
Acidity generated by the tumor microenvironment drives local invasion
Veronica Estrella,Tingan Chen,Mark C. Lloyd,Jonathan W. Wojtkowiak,Heather H. Cornnell,Arig Ibrahim-Hashim,Kate M. Bailey,Yoganand Balagurunathan,Jennifer M. Rothberg,Bonnie F. Sloane,Joseph O. Johnson,Robert A. Gatenby,Robert J. Gillies +12 more
TL;DR: Oral administration of sodium bicarbonate was sufficient to increase peritumoral pH and inhibit tumor growth and local invasion in a preclinical model, supporting the acid-mediated invasion hypothesis.
Journal ArticleDOI
Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy.
Shari Pilon-Thomas,Krithika Kodumudi,Asmaa El-Kenawi,Shonagh Russell,Amy Weber,Kimberly Luddy,Mehdi Damaghi,Jonathan W. Wojtkowiak,James J. Mulé,Arig Ibrahim-Hashim,Robert J. Gillies +10 more
TL;DR: Overall, the findings show how raising intratumoral pH through oral buffers therapy can improve responses to immunotherapy, with the potential for immediate clinical translation.
Journal ArticleDOI
A physical sciences network characterization of non-tumorigenic and metastatic cells
David B. Agus,Jenolyn F. Alexander,Wadih Arap,S.P. Ashili,Joseph E. Aslan,Robert H. Austin,Vadim Backman,Kelly Bethel,Richard Bonneau,Wei Chiang Chen,Chira Chen-Tanyolac,Nathan C. Choi,Steven A. Curley,Matthew R. Dallas,Dhwanil Damania,Paul Davies,Paolo Decuzzi,Laura E. Dickinson,Luis Estévez-Salmerón,Veronica Estrella,Mauro Ferrari,Claudia Fischbach,Jasmine Foo,Stephanie I. Fraley,Christian Frantz,Alexander Fuhrmann,Philippe Gascard,Robert A. Gatenby,Yue Geng,Sharon Gerecht,Robert J. Gillies,Biana Godin,William M. Grady,William M. Grady,Alex Greenfield,Courtney Hemphill,Barbara L. Hempstead,Abigail Hielscher,W. Daniel Hillis,Eric C. Holland,Arig Ibrahim-Hashim,Tyler Jacks,Roger H. Johnson,Ahyoung Joo,Jonathan E. Katz,Laimonas Kelbauskas,Carl Kesselman,Michael R. King,Konstantinos Konstantopoulos,Casey M. Kraning-Rush,Peter Kuhn,Kevin S. Kung,Brian J. Kwee,Johnathon N. Lakins,Guillaume Lambert,David Liao,Jonathan D. Licht,Jan Liphardt,Jan Liphardt,Liyu Liu,Mark C. Lloyd,Anna Lyubimova,Parag Mallick,Parag Mallick,John F. Marko,Owen J. T. McCarty,Deirdre R. Meldrum,Franziska Michor,Shannon M. Mumenthaler,Vivek Nandakumar,Thomas V. O'Halloran,Steve Oh,Renata Pasqualini,Matthew J. Paszek,Kevin G. Philips,Christopher S. Poultney,Kuldeepsinh Rana,Cynthia A. Reinhart-King,Robert Ros,Gregg L. Semenza,Patti Senechal,Michael L. Shuler,Srimeenakshi Srinivasan,Jack R. Staunton,Yolanda Stypula,Hariharan Subramanian,Thea D. Tlsty,Garth W. Tormoen,Yiider Tseng,Yiider Tseng,Alexander van Oudenaarden,Scott S. Verbridge,Scott S. Verbridge,Jenny C. Wan,Valerie M. Weaver,Jonathan Widom,Christine Will,Denis Wirtz,Jonathan W. Wojtkowiak,Pei Hsun Wu +99 more
TL;DR: Comparisons of the non-tumorigenic MCF-10A and metastatic MDA-MB-231 breast epithelial cell lines, commonly used as models of cancer metastasis, reveal dramatic differences in their mechanics, migration, adhesion, oxygen response, and proteomic profiles.
Journal ArticleDOI
Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
Zandra E. Walton,Chirag H. Patel,Rebekah C. Brooks,Yongjun Yu,Arig Ibrahim-Hashim,Malini Riddle,Alessandra Porcu,Alessandra Porcu,Tianying Jiang,Brett L. Ecker,Feven Tameire,Constantinos Koumenis,Ashani T. Weeraratna,David K. Welsh,David K. Welsh,Robert J. Gillies,James C. Alwine,Lin Zhang,Jonathan D. Powell,Chi V. Dang,Chi V. Dang,Chi V. Dang +21 more
TL;DR: A model in which acid produced during the cellular metabolic response to hypoxia suppresses the circadian clock through diminished translation of clock constituents is revealed.
Journal ArticleDOI
Hypoxia and acidosis: immune suppressors and therapeutic targets.
Sultan Damgaci,Arig Ibrahim-Hashim,Pedro M. Enriquez-Navas,Shari Pilon-Thomas,Albert Guvenis,Robert J. Gillies +5 more
TL;DR: The effects of hypoxia and acidosis on tumour immunity will be summarized, and how modulating these parameters and their sequelae can be a useful tool for future therapeutic interventions is discussed.