C
Christian H. K. Lehmann
Researcher at University of Erlangen-Nuremberg
Publications - 44
Citations - 1418
Christian H. K. Lehmann is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 17, co-authored 36 publications receiving 1009 citations. Previous affiliations of Christian H. K. Lehmann include University of Mainz.
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Journal ArticleDOI
FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo
Falk Nimmerjahn,Anja Lux,Heike Albert,Melissa Woigk,Christian H. K. Lehmann,Diana Dudziak,Patrick F. Smith,Jeffrey V. Ravetch +7 more
TL;DR: It is shown that a variety of IgG 2a- and IgG2b-dependent effector functions are impaired in the absence of this activating Fc receptor in models of autoimmunity and antibody-dependent cellular cytotoxicity.
Journal ArticleDOI
IL-9 and its receptor are predominantly involved in the pathogenesis of UC
Nancy Nalleweg,Mircea T. Chiriac,Eva Podstawa,Christian H. K. Lehmann,Tilman T. Rau,Raja Atreya,E Krauss,Gheorghe Hundorfean,Stefan Fichtner-Feigl,Arndt Hartmann,Christoph Becker,Jonas Mudter +11 more
TL;DR: Evidence is provided that IL- 9 is predominantly involved in the pathogenesis of UC suggesting that targeting IL-9 might become a therapeutic option for patients with UC.
Journal ArticleDOI
Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment
Gordon F. Heidkamp,Jil Sander,Christian H. K. Lehmann,Lukas Heger,Nathalie Eissing,Anna Baranska,Jennifer J. Lühr,Alana Hoffmann,Katharina C. Reimer,Anja Lux,Stephan Söder,Arndt Hartmann,Johannes Zenk,Thomas Ulas,Naomi McGovern,Christoph Alexiou,Bernd M. Spriewald,Andreas Mackensen,Gerold Schuler,Burkhard Schauf,Anja Forster,Roland Repp,Peter A. Fasching,Ariawan Purbojo,Robert Cesnjevar,Evelyn Ullrich,Evelyn Ullrich,Florent Ginhoux,Andreas Schlitzer,Andreas Schlitzer,Andreas Schlitzer,Falk Nimmerjahn,Joachim L. Schultze,Joachim L. Schultze,Diana Dudziak +34 more
TL;DR: It is demonstrated that DC subpopulations in organs of the lymphohematopoietic system (spleen, thymus, and blood) are strongly defined by ontogeny rather than by signals from the microenvironment, strongly arguing that DCs react toward modulatory signals from tissue microenvironments.
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Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer
Maria Paula Roberti,Maria Paula Roberti,Satoru Yonekura,Satoru Yonekura,Satoru Yonekura,Connie P.M. Duong,Connie P.M. Duong,Marion Picard,Marion Picard,Marion Picard,Gladys Ferrere,Gladys Ferrere,Maryam Tidjani Alou,Maryam Tidjani Alou,Conrad Rauber,Conrad Rauber,Conrad Rauber,Valerio Iebba,Valerio Iebba,Christian H. K. Lehmann,Lukas Amon,Diana Dudziak,Lisa Derosa,Lisa Derosa,Bertrand Routy,Bertrand Routy,Bertrand Routy,Caroline Flament,Caroline Flament,Corentin Richard,Romain Daillère,Romain Daillère,Aurélie Fluckiger,Aurélie Fluckiger,Isabelle Van Seuningen,Mathias Chamaillard,Audrey Vincent,Stephanie Kourula,Paule Opolon,Pierre Ly,Pierre Ly,Eugenie Pizzato,Eugenie Pizzato,Sonia Becharef,Sonia Becharef,Juliette Paillet,Juliette Paillet,Juliette Paillet,Christophe Klein,Florence Marliot,Filippo Pietrantonio,Stéphane Benoist,Jean-Yves Scoazec,Peggy Dartigues,Antoine Hollebecque,David Malka,Franck Pagès,Jérôme Galon,Ivo G. Boneca,Ivo G. Boneca,Patricia Lepage,Bernard Ryffel,Didier Raoult,Alexander M.M. Eggermont,Alexander M.M. Eggermont,Tom Vanden Berghe,François Ghiringhelli,Peter Vandenabeele,Guido Kroemer,Laurence Zitvogel +69 more
TL;DR: It is demonstrated that immunogenic ileal apoptosis contributes to the prognosis of chemotherapy-treated CC, and local microbiome composition influences treatment efficacy of chemotherapy in colon cancer via modulation of tolerogenic versus immunogenic IECs and the accumulation of T FH cells in patients with CC and mice.
Journal ArticleDOI
CLEC10A Is a Specific Marker for Human CD1c+ Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion.
Lukas Heger,Silke Balk,Jennifer J. Lühr,Gordon F. Heidkamp,Christian H. K. Lehmann,Lukas Hatscher,Ariawan Purbojo,Arndt Hartmann,Fayna Garcia-Martin,Shin-Ichiro Nishimura,Robert Cesnjevar,Falk Nimmerjahn,Diana Dudziak +12 more
TL;DR: CLEC10A represents not only a candidate to better define CD1c+ DCs—due to its high endocytic potential—but also exhibits an interesting candidate receptor for future antigen-targeting approaches.