C
Christina Ganster
Researcher at University of Göttingen
Publications - 33
Citations - 728
Christina Ganster is an academic researcher from University of Göttingen. The author has contributed to research in topics: Myelodysplastic syndromes & Medicine. The author has an hindex of 9, co-authored 28 publications receiving 373 citations. Previous affiliations of Christina Ganster include Medical University of Vienna.
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Journal ArticleDOI
Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes
Elsa Bernard,Yasuhito Nannya,Robert P. Hasserjian,Sean M. Devlin,Heinz Tuechler,Juan S. Medina-Martinez,Tetsuichi Yoshizato,Yusuke Shiozawa,Ryunosuke Saiki,Luca Malcovati,Max Levine,Juan E. Arango,Yangyu Zhou,Francesc Solé,Catherine Cargo,Detlef Haase,Maria Creignou,Ulrich Germing,Yanming Zhang,Gunes Gundem,Araxe Sarian,Arjan A. van de Loosdrecht,Martin Jädersten,Magnus Tobiasson,Olivier Kosmider,Matilde Y. Follo,Felicitas Thol,Ronald Feitosa Pinheiro,Valeria Santini,Ioannis Kotsianidis,Jacqueline Boultwood,Fabio P.S. Santos,Julie Schanz,Senji Kasahara,Takayuki Ishikawa,Hisashi Tsurumi,Akifumi Takaori-Kondo,Toru Kiguchi,Chantana Polprasert,John M. Bennett,Virginia M. Klimek,Michael R. Savona,Monika Belickova,Christina Ganster,Laura Palomo,Guillermo Sanz,Lionel Ades,Matteo G. Della Porta,Alexandra Smith,Yesenia Werner,Minal Patel,Agnes Viale,Katelynd Vanness,Donna Neuberg,Kristen E. Stevenson,Kamal Menghrajani,Kelly L. Bolton,Pierre Fenaux,Andrea Pellagatti,Uwe Platzbecker,Michael Heuser,Peter Valent,Shigeru Chiba,Yasushi Miyazaki,Carlo Finelli,Maria Teresa Voso,Lee Yung Shih,Michaela Fontenay,Joop H. Jansen,José Cervera,Yoshiko Atsuta,Norbert Gattermann,Benjamin L. Ebert,Rafael Bejar,Peter L. Greenberg,Mario Cazzola,Eva Hellström-Lindberg,Seishi Ogawa,Elli Papaemmanuil +78 more
TL;DR: Clinical sequencing across a large prospective cohort of patients with myelodysplasic syndrome uncovers distinct associations between the mono- and biallelic states of TP53 and clinical presentation.
Journal ArticleDOI
TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups
Detlef Haase,Kristen E. Stevenson,Donna Neuberg,Jaroslaw P. Maciejewski,Aziz Nazha,Mikkael A. Sekeres,Benjamin L. Ebert,Guillermo Garcia-Manero,Claudia Haferlach,Torsten Haferlach,Wolfgang Kern,Seishi Ogawa,Yasunobu Nagata,Kenichi Yoshida,Timothy A. Graubert,Matthew J. Walter,Alan F. List,Rami S. Komrokji,Eric Padron,David A. Sallman,Elli Papaemmanuil,Peter J. Campbell,Michael R. Savona,Adam C. Seegmiller,Lionel Adès,Pierre Fenaux,Lee-Yung Shih,David T. Bowen,Michael J. Groves,Sudhir Tauro,Michaela Fontenay,Olivier Kosmider,Michal Bar-Natan,David P. Steensma,Richard Stone,Michael Heuser,Felicitas Thol,Mario Cazzola,Luca Malcovati,Aly Karsan,Christina Ganster,Eva Hellström-Lindberg,Jacqueline Boultwood,Andrea Pellagatti,Valeria Santini,Lynn Quek,Paresh Vyas,Heinz Tüchler,Peter L. Greenberg,Rafael Bejar +49 more
TL;DR: The poor risk associated with CK-MDS is driven by its association with prognostically adverse TP53 mutations and can be refined by considering clinical and karyotype features.
Journal ArticleDOI
Therapy-related myelodysplastic syndromes deserve specific diagnostic sub-classification and risk-stratification-an approach to classification of patients with t-MDS
Andrea Kuendgen,M. Nomdedeu,Heinz Tuechler,G. Garcia-Manero,Rami S. Komrokji,Mikkael A. Sekeres,M.G. Della Porta,Mario Cazzola,Amy E. DeZern,Gail J. Roboz,David P. Steensma,A.A. van de Loosdrecht,Richard F. Schlenk,Richard F. Schlenk,Richard F. Schlenk,Javier Grau,Xavier Calvo,Sabine Blum,Arturo Pereira,Peter Valent,Dolors Costa,A.A.N. Giagounidis,Blanca Xicoy,Hartmut Döhner,Uwe Platzbecker,Carme Pedro,Michael Lübbert,Itziar Oiartzabal,María Díez-Campelo,Maria-Teresa Cedena,Sigrid Machherndl-Spandl,M. López-Pavía,Claudia D. Baldus,M. Martinez-de-Sola,Reinhard Stauder,Brayan Merchan,Alan F. List,Christina Ganster,Tobias Schroeder,Maria Teresa Voso,Michael Pfeilstöcker,Heinz Sill,Barbara Hildebrandt,Jordi Esteve,Benet Nomdedeu,Francesc Cobo,Rainer Haas,F. Solé,Ulrich Germing,Peter L. Greenberg,Detlef Haase,Guillermo Sanz +51 more
TL;DR: Analyzing data of 2087 t-MDS patients from different international MDS groups to evaluate classification and prognostication tools found that applying the WHO classification for p-M DS successfully predicts time to transformation and survival (both p < 0.001).
Journal ArticleDOI
New data shed light on Y-loss-related pathogenesis in myelodysplastic syndromes.
Christina Ganster,Dietrich Kämpfe,Klaus Jung,Friederike Braulke,Katayoon Shirneshan,Sigrid Machherndl-Spandl,Susanne Suessner,Carsten P. Bramlage,Tobias J. Legler,Michael Koziolek,Detlef Haase,Julie Schanz +11 more
TL;DR: It is concluded that LOY is clonal in a substantial number of MDS based on an age‐related predisposition and a threshold between age‐ and disease‐associated LOY in MDS is defined.
Journal ArticleDOI
DNA repair polymorphisms associated with cytogenetic subgroups in B‐cell chronic lymphocytic leukemia
Christina Ganster,Jürgen Neesen,Sonja Zehetmayer,Ulrich Jäger,Harald Esterbauer,Christine Mannhalter,Britta Kluge,Christa Fonatsch +7 more
TL;DR: The putative association of seven single nucleotide polymorphisms (SNPs) in five DNA repair genes with the incidence of chronic lymphocytic leukemia suggests that inborn genetic polymorphisms may predict the outcome of CLL.